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Regulation of raft architecture

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Summary

Raft membrane domains are envisioned as lateral assemblies of cholesterol and sphingolipids which adopt a liquid-ordered membrane phase. Our understanding of the raft architecture in cell membranes is developing rapidly. The current view describes raft domains as small and highly dynamic subdomains of cell membranes. The size and stability of raft domains are essential parameters which determine the function of raft domains in cells. Here we discuss how the architecture and stability of raft domains is regulated by oligomerisation of raft components and by modulation of their molecular composition.

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Abbreviations

DIGs:

detergent-insoluble glycolipid-enriched membranes

GPI:

glycosylphosphatidylinositol

PDZ:

PSD95/discslarge/ZO-1

PI:

phosphoinositide

PIP2 :

phosphatidylinositol 4,5-bisphosphate

TCR:

T-cell receptor

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Authors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 287, CH-4005, Basel, Switzerland

    T. Harder

  2. Department of Molecular and Cell Biology, University of California at Berkeley, California

    P. Scheiffele

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  1. T. Harder
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  2. P. Scheiffele
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Harder, T., Scheiffele, P. Regulation of raft architecture. Protoplasma 212, 1–7 (2000). https://doi.org/10.1007/BF01279341

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  • DOI: https://doi.org/10.1007/BF01279341

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