Andamento di alcune modificazione enzimatiche dei tessuti (adenilpirofosfatasi, rodanese) nelle varie fasi della infezione sperimentale da virus dell'encefalomiocardite (EMC)

Summary

In intracerebrally with EMC virus infected mice the adenylpyrophosphatase activity increases early starting from the 10th hour after infection both in cerebral and myocardial tissues and reaches the highest value at the 18th hour. From this time it remains at the same level in the cerebral, but drops in the myocardial tissue where at the 30th hour the enzymatic activity, even being still increased of + 17%, is no longer statistically significant.

On the other hand it has been shown that the rhodanese activity in cerebral and hepatic tissues is already at the 10th hour p. i. 29% respectively 33% lower than the normal values found in these tissues.

The significance of these metabolic modifications is discussed in relation to the viral multiplication and cellular damage through the different stages of the disease.