Studio biochimico dell'infezione sperimentale da virus dell'encefalomiocardite. Comportamento di alcune attività enzimatiche nel cervello, nel fegato e nel miocardio (adenilpirofosfatasi, succinodeidrogenasi, aspartico-chetoglutarico transaminasi, rodanese)

Summary

The determination of enzymatic activities (adenylpyrophosphatase, transaminase, succinodehydrogenase, rhodanese) in the brain, liver and myocard of mice infected with EMC virus both by the intraperitoneal and intracerebral route, yielded the following results:

• 1. Adenylpyrophosphatase: Statistically significant increase in all tested tissues of animals infected by both routes.

• 2. Aspartic-ketoglutaric transaminase: Statistically significant decrease in the liver and brain and myocard of mice infected by intraperitoneal route. Statistically significant decrease in the only liver and myocard of mice infected by intracerebral route.

• 3. Succinodehydrogenase: Statistically significant increase in the brain of mice infected by both routes. In the liver a significant variation has not been observed.

• 4. Rhodanese: Statistically significant decrease in the brain and liver only after intracerebral infection. In the intraperitoneally infected animals such a significant variation has not been observed.

The results are briefly discussed from the point of view of metabolic interpretation of the pathogenetic mechanism of viral infection.