Summary
The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning ∼ 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.
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Lesch, K.P., Balling, U., Gross, J. et al. Organization of the human serotonin transporter gene. J. Neural Transmission 95, 157–162 (1994). https://doi.org/10.1007/BF01276434
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DOI: https://doi.org/10.1007/BF01276434