Summary
Gluatamtergic fibers have been immunocytochemically localized in the entorhinal cortex of postmortem schizophrenic brains. The density of small caliber vertical fibers was higher in schizophrenics than controls, with no significant increase in the number of large caliber fibers. Increased glutamatergic fiber density has been previously reported in the cingulate cortex. It is proposed that increases in glutamatergic fibers from the amygdala may be responsible for these changes and that they may play a central role in the pathophysiology of schizophrenia.
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References
Amaral DG, Price JL, Pitkänen A, Carmichael ST (1992) Anatomical organization of the primate amygdaloid cortex. In: Aggleton JP (ed) The amygdala: neurobiological aspects of emotion, memory, and mental dysfunction. Wiley-Liss, New York, pp 1–66
Arnold SE, Hyman BT, Van Hoesen GW, Damasio AR (1991) Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 48(7): 625–632
Beall MJ, Lewis DA (1992) Heterogeneity of layer II neurons in human entorhinal cortex. J Comp Neurol 321(2): 241–266
Benes FM, Davidson J, Bird ED (1986) Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch Gen Psychiatry 43(1): 31–35
Benes FM, Majocha R, Bird ED, Marrotta CA (1987) Increased vertical axon numbers in cingulate cortex of schizophrenics. Arch Gen Psychiatry 44: 1017–1021
Benes F, Sorensen I, Vincent SL, Bird ED, Sathi M (1992) Increased density of glutamate-immunoreactive vertical processes in superficial laminae in cingulate cortex of schizophrenic brain. Cerebral Cortex 2: 503–512
Bogerts B (1993) Recent advances in the neuropathology of schizophrenia. Schizophr Bull 19(2): 431–445
Bogerts B, Meertz E, Schonfeldt-Bausch R (1985) Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Arch Gen Psychiatry 42(8): 784–791
Falkai P, Bogerts B (1986) Cell loss in the hippocampus of schizophrenics. Eur Arch Psychiatry Neurol Sci 236(3): 154–161
Jakob H, Beckmann H (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm 65: 303–326
Kim JS, Kornhuber W, Schmid-Burgk W, Holzmüller B (1980) Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20: 379–382
McDonald AJ, Beitz AJ, Larson AA, Kuriyama R, Sellitto C, Madl JE (1989) Co-localization of glutamate and tubulin in putative excitatory neurons of the hippocampus and amygdala: an immunohistochemical study using monoclonal antibodies. Neuroscience 30: 405–421
Reynolds GP (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature 305: 527–529
Van Hoesen GW, Morecraft RJ, Vogt BA (1993) Connections of the monkey cingulate cortex. In: Vogt B, Gabriel M (eds) Neurobiology of cingulate cortex and limbic thalamus. Birkhäuser, Boston, pp 249–284
Vonsattel JPG, Aizawa H, Ge P, DiFiglia M, McKee AC, MacDonald M, Gusella JF, Landwehrmeyer GB, Bird ED, Richardson EP, Hedley-Whyte ET (1995) An improved approach to prepare human brains for research. J Neuropathol Exp Neurol 54(1): 42–56
Witter MP (1993) Organization of the entorhinal-hippocampal system: a review of the current anatomical data. Hippocampus 3 (Special Issue): 33–44
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Longson, D., Deakin, J.F.W. & Benes, F.M. Increased density of entorhinal glutamate-immunoreactive vertical fibers in schizophrenia. J. Neural Transmission 103, 503–507 (1996). https://doi.org/10.1007/BF01276423
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DOI: https://doi.org/10.1007/BF01276423