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Investigational New Drugs

, Volume 10, Issue 1, pp 45–48 | Cite as

Response of metastatic adenoid cystic carcinoma and Merkel cell tumor to high-dose Melphalan with autologous bone marrow transplantation

  • William J. Slichenmyer
  • C. F. LeMaistre
  • Daniel D. Von Hoff
Brief Report

Summary

Two patients with metastatic spread of unusual tumors responded to treatment with high-dose Melphalan and autologous bone marrow transplant. One patient had adenoid cystic carcinoma of a minor salivary gland and the other had Merkel cell tumor of the scalp. Both patients had undergone prior surgery and radiotherapy, but later relapsed with distant metastases. Both patients had progression of their disease despite conventional and salvage chemotherapy. Treatment with high-dose Melphalan and autologous bone marrow transplant resulted in partial responses for both patients. High-dose Melphalan should be considered for therapy earlier in the course of patients with these unusual cancers.

Key words

Melphalan high-dose chemotherapy adenoid cystic carcinoma Merkel cell tumor autologous bone marrow transplantation L-phenylalanine mustard 

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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • William J. Slichenmyer
    • 1
    • 2
  • C. F. LeMaistre
    • 1
    • 2
  • Daniel D. Von Hoff
    • 1
    • 2
  1. 1.Division of Oncology, Department of MedicineUniversity of Texas Health Science CenterSan AntonioUSA
  2. 2.The Cancer Therapy and Research Center of South TexasUSA

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