Summary
Calbindin D28K is a neuronal calcium binding protein which may act as a buffer of neuronal calcium. Evidence suggests that disturbance of calcium homeostasis is important in neurodegeneration, possibly via changes in calbindin D28K. Immunoreactivity of calbindin D28K is compared in Alzheimer's disease and age-matched controls. The size and number of calbindin D28K positive neurons in Alzheimer's disease tissue is reduced. There is also shrinkage of the dendritic tree. Continuing work examines the function of calbindin D28K using transgenic mice.
References
Davenport AP, Augood SJ, Lawson DEM, Emson PC (1990) Calbindin D28K-like immunoreactivity in the rat brain. Cell Mol Biol 36: 1–11
Ghosh A, Greenberg ME (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268: 239–247
Hof PR, Morrison JH (1991) Neocortical subpopulations labeled by a monoclonalantibody to calbindin exhibit differential vulnerability in Alzheimer's disease. Exp Neurol 111: 293–301
Iacopino AM, Quintero EM, Miller EK (1994) Calbindin D28K: a potential neuroprotective protein. Neurodegeneration 3: 1–20
Ichimiya Y, Emson PC, Mountjoy CQ, Lawson DEM, Heizman CW (1988) Loss of calbindin D28K immunoreactive neurones from the cortex in Alzheimer-type dementia. Brain Res 475: 156–159
Ichimiya Y, Emson PC, Mountjoy CQ, Lawson DEM, Iizuka R (1989) Calbindin-immunoreactive neurones in the nucleus basalis of Meynert in Alzheimer-type dementia. Brain Res 499: 402–406
Kurobe N, Inaguma Y, Shimhara H, Semba R, Ingaki T, Kato K (1992) Developmental and age-dependent changes of 28 KDa calbindin D in the central nervous-tissue determined with a sensitive immunoassay method. J Neurochem 58: 128–134
Lledo P-M, Somasundaram B, Morton AJ, Emson PC, Mason WT (1992) Stable transfection of calbindin D28K into the GH3 cell line alters calcium currents and intracellular calcium homeostasis. Neuron 9: 943–954
Molinari S, Battini R, Ferrari S, Pozzi L, Killcross AS, Robbins TW, Jouvenceau A, Billard J-M, Dutar P, Lamour Y, Baker WA, Cox H, Emson PC (1996) Deficits in memory and hippocampal long-term potentiation in mice with reduced calbindin D28K expression. Proc Natl Acad Sci USA 93: 8028–8033
Schindler M, Sellers LA, Humphrey PPA, Emson PC (1997) Immunohistochemical localization of the somatostatin sst2 receptor in the rat brain and spinal cord. Neuroscience 76: 225–240
Thibault O, Landfield PW (1996) Increase in single L-type calcium channels in hippocampal neurons during aging. Science 272: 1017–1020
Wasserman RH, Taylor AN (1966) Vitamin D3-induced calcium-binding protein in chick intestinal mucosa. Science 152: 791–793
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Lally, G., Faull, R.L.M., Waldvogel, H.J. et al. Calcium homeostasis in ageing: Studies on the calcium binding protein calbindin D28K . J. Neural Transmission 104, 1107–1112 (1997). https://doi.org/10.1007/BF01273323
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DOI: https://doi.org/10.1007/BF01273323