Skip to main content
SpringerLink
Log in

The antagonism of ipsapirone induced biobehavioral responses by +/− pindolol in high and low impulsives

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

The present study was conducted to investigate whether +/− pindolol antagonizes ipsapirone induced biobehavioral changes in a personality dependent way. Our previous work demonstrated that high impulsives show higher immune cell responses than low impulsive subjects upon treatment with ipsapirone. A total number of 80 healthy male volunteers received placebo (N=20) or 10 mg ipsapirone (N=20), 30 mg +/− pindolol (N=20), or a combination of 30 mg +/− pindolol and 10 mg ipsapirone (N=20). Each group consisted of 10 low and 10 high impulsive subjects. Since 5-HT related drugs induce thermoregulatory responses, the study took place in a climate chamber with a constant ambient temperature. Blood samples (for measurement of CD4+ cell counts) were drawn from an indwelling catheter invisibly for the subjects. The results clearly demonstrate that the ipsapirone induced decreases in body temperature and number of peripheral CD4+ cells are more pronounced in high impulsives. +/− Pindolol antagonizes the thermoregulatory and CD4+ cell responses. The results are discussed with respect to mechanisms of alteration in 5-HT function related to impulsivity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aulakh CS, Tolliver T, Wozniak KM, Hill JL, Murphy DL (1994) Functional and biochemical evidence for altered serotonergic function in the fawn-hooded rat strain. Pharmacol Biochem Behav 49: 615–620

    Google Scholar 

  • Aune TM, McGrath KM, Sarr T, Bombara MP, Kelley KA (1993) Expression of 5-HT1a receptors on activated human T-cells. J Immunol 151: 1175–1183

    Google Scholar 

  • Bagdy G, Makara GB (1994) Hypothalamic paraventricular nucleus lesions differentially affect serotonin-1A (5-HT1A) and 5-HT2 receptor agonist-induced oxytocin, prolactin, and corticosterone responses. Endocrinol 134: 1127–1131

    Google Scholar 

  • Basse Tomusk A, Rebec GV (1986) Ipsapirone depresses neuronal activity in the dorsal raphe nucleus and the hippocampal formation. Eur J Pharmacol 130: 141–143

    Google Scholar 

  • Beneke M, Wingender W, Horstmann R, Konrad-Dalhoff I, Weber H, Kuhlmann J, Schmidt BH (1992) Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers. Eur J Clin Pharmacol 42: 163–169

    Google Scholar 

  • Benton D, Nastiti K (1988) The influence of psychotropic drugs on the ultrasonic calling of mouse pups. Psychopharmacol Berl 95: 99–102

    Google Scholar 

  • Coccaro EF (1992) Impulsive aggression and central serotonergic system functioning in humans: an example of a dimensional brain-behavior relationship. Int Clin Psychopharmacol 7: 3–12

    Google Scholar 

  • Coccaro EF, Gabriel S, Siever LJ (1990) Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans. Psychopharmacol Bull 26: 393–405

    Google Scholar 

  • Cowen PJ, Anderson IM, Gartside SE (1990) Endocrinological responses to 5-HT. Ann NY Acad Sci 600: 250–257

    Google Scholar 

  • Cutler MG, Dixon AK (1988) Effects of ipsapirone on the behaviour of mice during social encounters. Neuropharmacol 27: 1039–1044

    Google Scholar 

  • Dinan TG (1996) Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function. Life Sci 58: 1683–1694

    Google Scholar 

  • Eysenck SBG, Eysenck HJ (1978) Impulsivity and venturesomeness: their position in a dimensional system of personaltiy description. Psychol Rep 43: 1247–1255

    Google Scholar 

  • Finocchiaro LME, Arzt ES, Fernandez-Castelo S, Criscuolo M, Finkielman S, Nahmod VE (1988) Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferone gamma a part of an immunomodulatory pathway. J Interferon Res 8: 705

    Google Scholar 

  • Gelfin Y, Lerer B, Lesch KP, Gorflne M, Allolio B (1995) Complex effects of age and gender on hypothermic, adrenocorticotrophic hormone and cortisol responses to ipsapirone challenge in normal subjects. Psychopharmacology Berl 120: 356–364

    Google Scholar 

  • Gilbert F, Brazell C, Tricklebank MD, Stahl SM (1988) Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration. Eur J Pharmacol 147: 431–439

    Google Scholar 

  • Goodwin GM, Murray CL, Bancroft J (1994) Oral D-fenfluramine and neuroendocrine challenge: problems with the 30 mg dose in men. J Affect Disord 30: 117–122

    Google Scholar 

  • Haj Dahmane S, Hamon M, Lanfumey L (1991) K+ Channel and 5-hydroxytryptamine1A autoreceptor interactions in the rat dorsal raphe nucleus: an in vitro electrophysiological study. Neuroscience 41: 495–505

    Google Scholar 

  • Hennig J, Laschefski U, Becker H, Rammsayer T, Netter P (1993) Immune cell and cortisol responses to physically and pharmacologically induced lowering of body core temperature. Neuropsychobiol 28: 82–86

    Google Scholar 

  • Hennig J, Becker H, Netter P (1996) 5-HT agonist induced changes in peripheral immune cells in healthy volunteers: the impact of personality. Behav Brain Res 73: 359–363

    Google Scholar 

  • Jolas T, Schreiber R, Laporte AM, Chastanet M, De-Vry J, Glaser T, Adrien J, Hamon M (1995) Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? J Pharmacol Exp Ther 272: 920–929

    Google Scholar 

  • Kahn RS, Trestman R, Lawlor BA, Gabriel S, Davidson M, Siever L (1994) Effects of ipsapirone in healthy subjects: a dose-response study. Psychopharmacology Berl 114: 155–160

    Google Scholar 

  • Kirschbaum C, Strasburger CJ, Jammers W, Hellhammer DH (1989) Cortisol and behavior. 1. Adaptation of a radioimmunoassay kit for reliable and inexpensive salivary cortisol determination. Pharmacol Biochem Behav 34: 747–751

    Google Scholar 

  • Koenig JI, Meltzer HY, Gudelsky GA (1988) 5-Hydroxytryptamine1A receptor-mediated effects of buspirone, gepirone and ipsapirone. Pharmacol Biochem Behav 29: 711–715

    Google Scholar 

  • Korte SM, Bouws GA, Koolhaas JM, Bohus B (1992) Neuroendocrine and behavioral responses during conditioned active and passive behavior in the defensive burying/probe avoidance paradigm: effects of ipsapirone. Physiol Behav 52: 355–361

    Google Scholar 

  • Lesch KP (1991) 5-HT1A receptor responsivity in anxiety disorders and depression. Prog Neuropsychopharmacol Biol Psychiatry 15: 723–733

    Google Scholar 

  • Lesch KP, Rupprecht R, Poten B, Muller U, Sohnle K, Fritze J, Schulte HM (1989) Endocrine responses to 5-hydroxytryptamine-1A receptor activation by ipsapirone in humans. Biol Psychiatry 26: 203–205

    Google Scholar 

  • Lesch KP, Disselkamp Tietze J, Schmidtke A (1990a) 5-HT1A receptor function in depression: effect of chronic amitriptyline treatment. J Neural Transm [Gen Sect] 80: 157–161

    Google Scholar 

  • Lesch KP, Mayer S, Disselkamp Tietze J, Hoh A, Schoellnhammer G, Schulte HM (1990b) Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression. Life Sci 46: 1271–1277

    Google Scholar 

  • Lesch KP, Poten B, Sohnle K, Schulte HM (1990c) Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans. Eur J Clin Pharmacol 39: 17–19

    Google Scholar 

  • Lesch KP, Hoh A, Disselkamp Tietze J, Wiesmann M, Osterheider M, Schulte HM (1991a) 5-Hydroxytryptamine1A receptor responsivity in obsessive-compulsive disorder. Comparison of patients and controls. Arch Gen Psychiatry 48: 540–547

    Google Scholar 

  • Lesch KP, Hoh A, Schulte HM, Osterheider M, Muller T (1991b) Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obseslsive-compusive disorder. Psychopharmacology Berl 105: 415–420

    Google Scholar 

  • Lesch KP, Wiesmann M, Hoh A, Muller T, Disselkamp-Tietze J, Osterheider M, Schulte HM (1992) 5-HT1A receptor-effector system responsivity in panic disorder. Psychopharmacology Berl 106: 111–117

    Google Scholar 

  • Lorens SA, Van de Kar LD (1987) Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology 45: 305–310

    Google Scholar 

  • Maj J, Chojnacka Wojcik E, Tatarczynska E, Klodzinska A (1987) Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. J Neural Transm 70: 1–17

    Google Scholar 

  • Martin KF, Phillips I, Hearson M, Prow MR, Heal DJ (1992) Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. Br J Pharmacol 107: 15–21

    Google Scholar 

  • Owens MJ, Edwards E, Nemeroff CB (1990) Effects of 5-HT1A receptor agonists on hypothalamo-pituitary-adrenal axis activity and corticotropin-releasing factor containing neurons in the rat brain. Eur J Pharmacol 190: 113–122

    Google Scholar 

  • Schmidt BH, Chaouloff F (1993) Chronic treatment with an anxiolytic dose of the 5-HT1A agonist ipsapirone does not alter ipsapirone acute neuroendocrine effects. Psychoneuroendocrinology 18: 457–466

    Google Scholar 

  • Stahl SM (1992) Neuroendocrine markers of serotonin responsivity in depression. Prog Neuropsychopharmacol Biol Psychiatry 16: 655–659

    Google Scholar 

Download references

Author information

Author notes

  1. J. Hennig

    Present address: Department of Psychology, University of Giessen, Federal Republic of Germany

Authors and Affiliations

  1. Department of Psychology, University of Giessen, Federal Republic of Germany

    S. Huwe & P. Netter

  2. Department of Physiological Chemistry, Section Neurochemistry, University of Marburg, Federal Republic of Germany

    C. Opper

Authors
  1. J. Hennig
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Opper
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Huwe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Netter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hennig, J., Opper, C., Huwe, S. et al. The antagonism of ipsapirone induced biobehavioral responses by +/− pindolol in high and low impulsives. J. Neural Transmission 104, 1027–1035 (1997). https://doi.org/10.1007/BF01273316

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01273316

Keywords

Search

Navigation