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Inositol treatment of autism

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  • Biological Psychiatry
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Recent studies suggest that serotonin reuptake inhibitors are helpful in at least some symptoms of autism. Inositol is a precursor of the second messenger for some serotonin receptors, and has been reported effective in depression, panic disorder and obsessive-compulsive disorder. However a controlled double-blind crossover trial of inositol 200 mg/kg per day showed no benefit in 9 children with autism. Since biochemical studies suggest that inositol may augment serotonin effects, future studies could evaluate inositol in children already receiving serotonin reuptake inhibitors.

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Levine, J., Aviram, A., Holan, A. et al. Inositol treatment of autism. J. Neural Transmission 104, 307–310 (1997).

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