Summary
The possible role of histamine (HA) locally applied into the hippocampus on memory mechanisms of the rats was studied. The acquisition of a one-way active avoidance response to an ultrasonic 40 kHz sinus-wave tone anticipating an electric shock was used as experimental model. Learning sessions consisted in placing animals into a two compartment cage were they learnt to escape to the safe compartment after an ultrasonic tone anticipating an electric feet shock. After acquiring the conditioned avoidance response, animals were implanted with microinjection cannulae and injected with 1 μl of saline, or increasing doses of histamine (9, 22.5, 45, and 90nmol) into the hippocampus. In the experimental sessions, 4 trials before (PRE) and 4 trials afterward treatment (POST), the percentage of conditioned avoidance responses (% CAR) and the latency time to escape (LT) were measured. Results showed that HA increased significantly the LT and this effect was grossly dose-dependent. % CAR was also affected and the score was significantly inhibited by the imidazolamine administration. Results suggest that HA may be involved in memory retrieval processes in the hippocampus.
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Alvarez EO, Banzan AM (1990) Behavioral effects of GABA in the hippocampal formation: functional interaction with histamine. Behav Brain Res 37: 133–143
Alvarez EO, Banzan AM (1992) The role of histamine in the anterior hypothalamus and its functional interaction with the hippocampus on exploratory behavior in adult male rats. Behav Brain Res 48: 127–133
Bianchin M, Walz R, Ruschel AC, Zanatta MS, Da Silva RC, Bueno e Silvia M, Paczko N, Medina JH, Izquierdo I (1993) Memory expression is blocked by the infusion of CNQX into the hippocampus and/or the amygdala up to 20 days after training. Behav Neural Biol 59: 83–86
Bealer SL (1993) Histamine releases norepinephrine in the paraventricular nucleus/anterior hypothalamus of the conscious rat. J Pharmacol Exp Ther 264: 734–738
Clapham J, Kilpatrick GJ (1992) Histamine H3 receptors modulate the release of [3H]-acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes. B J Pharmacol: 919–923
Fleckenstein AE, Lookingland KJ, Moore KE (1994) Effects of histamine on 5-hydroxytryptaminergic neuronal activity in the rat hypothalamus. Eur J Pharmacol 254: 35–42
Hörtnagl H, Sperk G, Sobal G, Maas D (1990) Cholinergic deficit induced by ethylcholine aziridinium (AF64A) transiently affects somatostatin and neuropeptide Y levels in the rat brain. J Neurochem 54: 1608–1613
Hörtnagl H, Berger ML, Sperk G, Pifl Ch (1991) Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus. Neuroscience 45: 261–272
Inagaki N, Yamatodani A, Ando-Yamamoto M, Tohyama M, Watanabe T, Wada H (1988) Organization of histaminergic fibers in the rat brain. J Comp Neurol 273: 283–300
Izquierdo I, Bianchin M, Bueno e Silva M, Zanatta MS, Waltz R, Ruschel AC, Da Silva RC, Pazko N, Medina JH (1993) CNQX infused into rat hippocampus or amygdala disrupts the expression of memory of two different tasks. Behav Neural Biol 59: 1–4
McDonald RJ, White NM (1993) A triple dissociation of memory systems: hippocampus, amygdala, and dorsal striatum. Behav Neurosci 107: 3–22
Nilsson OG, Brundin P, Björklund A (1990) Amelioration of spatial memory by intrahippocampal grafts of mixed septal and raphe tissue in rats with combined cholinergic and serotonergic denervation of the forebrain. Brain Res 515: 193–206
O'Keefe J (1990) A computational theory of the hippocampal cognitive map. Prog Brain Res 83: 301–312
Palacios JM, Wamsley JK, Kuhar MJ (1981) The distribution of histamine HI receptors in the brain: an autoradiographic study. Neuroscience 6: 15–37
Richter-Levin G, Segal M (1989) Spatial performance is severely impaired in rats with combined reduction of serotonergic and cholinergic transmission. Brain Res 477: 404–407
Save E, Buhot MC, Foreman N, Thinus-Blanc C (1992) Exploratory activity and response to a spatial change in rats with hippocampal or posterior parietal cortical lesions. Behav Brain Res 47: 113–127
Schlicker E, Behling A, Lümmen G, Göthert M (1992a) Histamine H3A receptormediated inhibition of noradrenaline release in the mouse brain cortex. Naunyn Schmiedebergs Arch Pharmacol 345: 489–493
Schlicker E, Behling A, Lümmen G, Malinowska B, Göthert M (1992b) Mutual interaction of histamine H3-receptors and α2-adrenoceptors on noradrenergic terminals in mouse and rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol 345: 639–646
Schmajuk NA, DiCarlo JJ (1992) Stimulus configuration, classical conditioning, and hippocampal function. Psychol Rev 99: 268–305
Thinus-Blanc C, Save E, Poucet B, Buhot MC (1991) The effects of reversible inactivations of the hippocampus on exploratory activity and spatial memory. Hippocampus 1: 365–372
Vanderwolf CH (1987) Near-total loss of “learning” and “memory” as a result of combined cholinergic and serotonergic blockade in the rat. Behav Brain Res 23: 43–57
Van-Reempts J, Dikova M, Werbrouck L, Clincke G, Borgers M (1992) Synaptic plasticity in the rat hippocampus associated with learning. Behav Brain Res 51: 179–183
Volpe B, Davis HP, Towle A, Dunlap WP (1992) Loss of hippocampal CA1 pyramidal neurons correlates with memory impairment in rat with ischemie or neurotoxin lesions. Behav Neurosci 106: 457–464
Vorobjev VS, Sharonova IN, Walsh IB, Haas HL (1993) Histamine potentiates N-methyl-D-aspartate responses in acutely isolated hippocampal neurons. Neuron 11: 837–844
Weskamp G, Lorez HP, Keller HH, Otten U (1986) Cholinergic but not monoaminergic denervation increases nerve growth factor content in the adult rat hippocampus and cerebral cortex. Naunyn Schmiedebergs Arch Pharmacol 334: 346–351
Zola-Morgan S, Squire LR (1993) Neuroanatomy of memory. Annu Rev Neurosci 16: 547–563. 21
Zola-Morgan S, Squire LR, Rempel N, Clower RL (1992) Enduring memory impairment in monkey after ischemic damage to the hippocampus. J Neurosci 12: 2582–2596
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Alvarez, E.O., Banzan, A.M. Effects of localized histamine microinjections into the hippocampal formation on the retrieval of a one-way active avoidance response in rats. J. Neural Transmission 101, 201–211 (1995). https://doi.org/10.1007/BF01271557
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DOI: https://doi.org/10.1007/BF01271557