Summary
CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression. We studied CSF inositol in 18 drug-free depressed patients and 36 normal controls; the depressed patients then participated in an open trial of 18 gm daily inositol treatment for 4 weeks. There was no difference in pre-treatment CSF inositol between depressed patients and controls. CSF inositol levels did not predict response on the Hamilton Depression Scale to 4 weeks of inositol treatment.
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Levine, J., Kurtzman, L., Rapoport, A. et al. CSF inositol does not predict antidepressant response to inositol. J. Neural Transmission 103, 1457–1462 (1996). https://doi.org/10.1007/BF01271260
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DOI: https://doi.org/10.1007/BF01271260