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Occurrence and functions of the phosphatidylinositol cycle in the myocardium

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Abstract

In the last decade a great deal of attention was awarded to a signal transduction pathway which is utilized primarily by ‘Ca2+ mobilizing’ signal molecules and which involves the hydrolysis of a quantitatively minor phospholipid, phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by a PtdIns-specific phospholipase C (PLC). The evidence for the existence of receptor-mediated GTP binding protein-coupled PLC in myocardium and its possible functions are briefly summarized. The minireview is concentrated on the following aspects: 1) cellular localization and synthesis of polyphospho-PtdIns from PtdIns, 2) desensitization of the α1-adrenergic agonist and endothelin-1 mediated PtdIns responses, 3) oscillatory Ca2+ transients initiated by Ptdlns(4,5)P2 hydrolysis, 4) polyunsaturated fatty acids as constituents of polyphospho-PtdIns and of the protein kinase C activator 1,2-diacylglycerol (DAG), 5) source other than Ptdlns(4,5)P2 contributing to the stimulated DAG, 6) role of the PtdIns pathway in cardiomyocyte growth and gene expression during the hypertrophic response. (Mol Cell Biochem116: 59–67, 1992)

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Abbreviations

Phosphatidylinositol 4,5-bisphosphate:

PtdIns(4,5)P2

Phosphatidylinositol 4-monophosphate:

PtdIns(4)P4

Phosphatidylinositol:

PtdIns

Inositol 1,4,5-triphosphate:

Ins(1,4,5)P3

Inositol 1,3,4,5-tetrakisphosphate:

Ins(1,3,4,5)P4

Inositol 1-monophosphate:

Ins(1)P

Inositol 1,4-bisphosphate:

Ins(1,4)P2

Inositol:

Ins

Inositolphosphates:

InsPn

Guanine 5'-triphosphate:

GTP

GTP binding protein:

G-protein

Phosphatidylinositolspecific phospholipase C:

PLC

Protein kinase C:

PKC

1,2-Diacylglycerol:

DAG

Monoacylglycerol:

MAG

cytidyldiphoshate-diacylglycerol:

CDP-DAG

Sarcolemma:

SL

Sarcoplasmic reticulum:

SR

Stearic acid:

18:0

Polyunsaturated fatty acids:

PUFA

Arachidonic acid:

20:4n-6

Linoleic acid:

18:2n-6

Eicosapentaenoic acid:

20:5n-3

Docosahexaenoic acid:

22:6n-3

Phosphatidic acid:

PtdOH

Phospholipase D:

PLD

Phosphatidylcholine:

PtdChol

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, 3000 DR, Rotterdam, The Netherlands

    Johanna T. A. Meij

  2. Department of Physiology, Division of Cardiovascular Sciences, Faculty of Medicine, University of Manitoba, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada

    Jos M. J. Lamers, Dick H. W. Dekkers, Karel Bezstarosti & Han A. A. van Heugten

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  1. Jos M. J. Lamers
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  4. Johanna T. A. Meij
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Lamers, J.M.J., Dekkers, D.H.W., Bezstarosti, K. et al. Occurrence and functions of the phosphatidylinositol cycle in the myocardium. Mol Cell Biochem 116, 59–67 (1992). https://doi.org/10.1007/BF01270570

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