Abstract
The influence of induction of antibodies to the neuromediator serotonin in the case of active immunization of animals with a conjugate serotonin-protein antigen on the distribution of biogenic amines in the brain and on behavioral responses was investigated in experiments on rats. It was shown that active immunization of rats with a serotonin-protein conjugate leads to a decrease in serotonin, its metabolite 5-hydroxyindole-3-acetic acid, as well as dopamine in certain brain structures. Against a background of induction of antibodies to serotonin, the horizontal motor activity of the animals is decreased.
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Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 74, No. 10, pp. 1367–1372, October, 1988.
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Basharova, L.A., Vetrilé, L.A., Evseev, V.A. et al. Influence of active immunization of rats with conjugated serotonin-protein antigen on the content of biogenic amines in the brain and on behavioral responses. Neurosci Behav Physiol 20, 109–113 (1990). https://doi.org/10.1007/BF01268129
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DOI: https://doi.org/10.1007/BF01268129