Summary
A total of 67 children aged 6 to 18 months were immunized with a formalin-killed, concentrated measles vaccine. All except one child were seronegative to measles prior to vaccination as measured by neutralization, HI and CF tests. Three doses of 0.5 to 1 ml. of vaccine were given at monthly intervals to all children, save for five children who received two doses only. Among 55 children, which were fully vaccinated and were not exposed to measles during the course of immunization, antibodies were detected in 54 (98%) with HI tests and in 51 (93%) with neutralization tests, whereas CF tests demonstrated conversions in 42 (76%) children only. The serum titers reached were about half those demonstrable after a natural measles infection. Children, supposedly exposed to measles in the course of the trial responded with serum titers about twice as high as those appearing after a natural infection. A similar booster effect was demonstrated in the single child of the group with a prevaccination serum titer. The serum titers of children, who received only two doses of vaccine were considerably lower than those reached after a full course of three doses.
A high correlation between neutralizing and HI antibodies was found, the sensitivity of the HI test being about 7 times greater than that of the neutralization tests. A correlation was also demonstrable between CF and neutralizing as well as HI serum titers.
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Carter, C. H., T. J. Conway, D. Cornfeld, D. G. Iezzoni, C. H. Kempe,C. Moscovici, L. W. Rauh, A. J. Vignec, andJ. Warren: J. A. M. A.179, 848 (1962).
Cutchins, E. C.: J. Immunol.88, 788 (1962).
Enders, J. F., S. L. Katz, M. V. Milanović, andAnn Holloway: New Engl. J. Med.263, 153 (1960).
Frankel, J. W., E. A. Wilton, L. Potkonski, andW. P. Boger: Proc. Soc. Exp. Biol. a. Med.110, 154 (1962).
Hilleman, M. R., J. Stokes, Jr.,E. B. Buynak, C. M. Reilly, andB. Hampil: Am. J. Dis. Childr.103, 242 (1962).
Katz, S. L., J. F. Enders, andAnn Holloway: New Engl. J. Med.263, 159 (1960).
Norrby, E.: Proc. Soc. Exp. Biol. a. Med.111, 814 (1962).
Ruckle, G., andK. D. Rogers: J. Immunol.78, 341 (1957).
Stokes, J. Jr.,M. R. Hilleman, R. E. Weibel, E. B. Buynak, R. Halenda, andH. Goldner: New Engl. J. Med.265, 507 (1961).
Stokes, J., Jr.,C. M. Reilly, E. B. Buynak, andM. R. Hilleman: Am. J. Hyg.74, 293 (1961).
Svedmyr, A., J. F. Enders, andAnn Holloway: Proc. Soc. Exp. Biol. a. Med.79, 296 (1952).
Warren, J., andM. J. Gallian: Am. J. Dis. Childr.103, 216 (1962).
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Norrby, E., Lagercrantz, R., Gard, S. et al. Measles vaccination. Archiv f Virusforschung 13, 548–558 (1963). https://doi.org/10.1007/BF01267797
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DOI: https://doi.org/10.1007/BF01267797