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Physical bone changes in carragheenin-induced arthritis evaluated by quantitative computed tomography

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Abstract

Repeated non-invasive measurements were performed in dogs of trabecular bone density (TBD), low density bone area (LDBA), and high density bone area (HDBA) in chronic arthritis using quantitative computed tomography (QCT). Unilateral chronic arthritis of the knee had been induced by weekly instillation of 2 ml carragheenin into the right knee joint for 12 weeks with the left knee serving as a control. CT scanning of the distal femoral condyles was performed in 12 mature dogs with chronic arthritis. Another 6 dogs underwent a longitudinal CT study starting immediately prior to induction of arthritis. During induction of arthritis TBD decreased (P<0.01), LDBA increased (P<0.05) and HDBA decreased (P<0.01) in the arthritic bone. Opposite changes were found on the control side, i.e. TBD increased (P<0.01), LDBA decreased (P<0.01) and HDBA increased (P<0.01). The chronic arthropathic bone showed 20% lower TBD (P< 0.0001), greater LDBA (P<0.0001) and lower HDBA (P<0.0001) as compared with the control bone. Reproducibility tests of TBD showed a coefficient of variation of 0.8%. Indentation tests and histomorphometric analyses confirmed the bone density changes as measured by CT.

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Authors and Affiliations

  1. Biomechanics Laboratory, Orthopaedic Hospital, University of Aarhus, Denmark

    Kjeld Søballe M.D., Anders Odgaard M.D., Ebbe S. Hansen M.D., Ivan Hvid M.D., Ph.D. & Cody Bünger M.D., Ph.D.

  2. Institute of Experimental Clinical Research, University of Aarhus, Denmark

    Kjeld Søballe M.D., Gitte I. Juhl M.D. & Ebbe S. Hansen M.D.

  3. Department of Diagnostic Radiology R, Aarhus Kommunehospital, University of Aarhus, Denmark

    Claus M. Pedersen M.D.

  4. Institute of Pathology, Aarhus Amtssygehus, University of Aarhus, Denmark

    Helle B. Rasmussen M.D.

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  1. Kjeld Søballe M.D.
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Søballe, K., Pedersen, C.M., Odgaard, A. et al. Physical bone changes in carragheenin-induced arthritis evaluated by quantitative computed tomography. Skeletal Radiol. 20, 345–352 (1991). https://doi.org/10.1007/BF01267662

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