Skip to main content


Log in

Femoral infarction following intraarterial chemotherapy for osteosarcoma of the leg: a possible pitfall in magnetic resonance imaging

  • Articles
  • Published:
Skeletal Radiology Aims and scope Submit manuscript


Bone infarction of the distal femur is reported in two patients with osteosarcoma of the leg (1 tibia, 1 fibula) treated by preoperative chemotherapy including intraarterial chemotherapy (IAC) by Cis-platinum.

Both patients were examined by magnetic resonance imaging before chemotherapy and again prior to limb salvage surgery.

The location of these lesions in the distal femur must suggest bone infarction especially if the tumor has decreased in size under treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Benjamin RS (1989) Regional chemotherapy of osteosarcoma. Semin Oncol 16:323

    PubMed  Google Scholar 

  2. Carrasco CH, Charnsangavej C, Richli WR, Wallace S (1987) Intra-arterial cis-platinum in osteosarcoma. In: Neth R, Gallo RC, Greaves MF, Kabisch H (eds) Modern trends in human leukemia. VII. Springer, Berlin Heidelberg New York, p 52 (Haematology and Blood Transfusion, vol 31)

    Google Scholar 

  3. Carrasco CH, Charnsangavej C, Richli WR, Raymond AK, Wallace S, Benjamin RS (1989) Osteosarcoma: interventional radiology in diagnosis and management. Semin Roentgenol 24:193

    PubMed  Google Scholar 

  4. Erlemann R, Sciuck J, Bosse A, Ritter J, Kusnierz-Glaz CR, Peters PE, Wuisman P (1990) Response of osteosarcoma and Ewing sarcoma to preoperative chemotherapy: assessment with dynamic and static MR imaging and skeletal scintigraphy. Radiology 175:791

    PubMed  Google Scholar 

  5. Holscher HC, Bloem JM, Nooy MA, Taminiau AHM, Eulderink F, Hermans J (1990) The value of MR imaging in monitoring the effect of chemotherapy on bone sarcomas. AJR 154:763

    PubMed  Google Scholar 

  6. Munk PL, Helms CA, Holt RG (1989) Immature bone infarcts: findings on plain radiographs and MR scans. AJR 152:547

    PubMed  Google Scholar 

  7. Pan G, Raymond AK, Carrasco CH, Wallace S, Kim EE, Shirkhoda A, Jaffe N, Murray JA, Benjamin RS (1990) Osteosarcoma: MR imaging after preoperative chemotherapy. Radiology 174:517

    PubMed  Google Scholar 

  8. Rao VM, Fischman M, Mitchell DG, Steiner RM, Ballas SK, Axel I., Dalinka MK, Gefter W, Kressel HY (1986) Painful sickle cell crisis: bone marrow patterns observed with MR imaging. Radiology 161:211

    PubMed  Google Scholar 

  9. Sanchez RB, Quinn SF, Walling A, Estrada J, Greenberg H (1990) Musculoskeletal neoplasm after intraarterial chemotherapy: correlation of MR images with pathologic specimens. Radiology 174:237

    PubMed  Google Scholar 

  10. Stine KC, Hockenberry MJ, Harrelson J, Miner D, Faletta JM (1989) Systemic doxorubicin and intraarterial cisplatin preoperative chemotherapy plus postoperative adjuvant chemotherapy in patients with osteosarcoma. Cancer 63:848

    PubMed  Google Scholar 

  11. Vanel D, Di Paolo R, Contesso G (1987) Magnetic resonance imaging in musculoskeletal primary malignant tumors. In: Kressel HY (ed) Magnetic resonance annual. Raven, New York, p 237

    Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Ollivier, L., Leclere, J., Vanel, D. et al. Femoral infarction following intraarterial chemotherapy for osteosarcoma of the leg: a possible pitfall in magnetic resonance imaging. Skeletal Radiol. 20, 329–332 (1991).

Download citation

  • Issue Date:

  • DOI:

Key words