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Dose-response relationships for inorganic lead

II. Subjective and functional responses — Chronic sequelae —no-response levels

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Summary

Following a proposal of dose-response (D-R) relationships for various biochemical and haematological parameters in part I, this paper discusses D-R-relationships for subjective and functional responses and for chronic sequelae. Lead in blood levels (PbB) are regarded as “internal dose”. It appears not to be possible to suggest adequate D relationships; however various no-response levels could be suggested. The concept of no-response level and of D-R-relationship is reevaluated. Various interfering factors are mentioned, which allow only approximative answers in regard to no-response levels and place and/or shape of D-Rcurves. An overall view of the D-R-relationships presented endorses the previously proposed Biological Quality Guide for the distribution of PbB levels within a population group: adherence to this guide very probably will prevent any health impairment in children and adults.

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Authors and Affiliations

  1. Coronel Laboratory Faculty of Medicine, University of Amsterdam, 1. Constantijn Huygensstraat 20, Amsterdam, Netherlands

    R. L. Zielhuis

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  1. R. L. Zielhuis
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Zielhuis, R.L. Dose-response relationships for inorganic lead. Int. Arch Occup Environ Heath 35, 19–35 (1975). https://doi.org/10.1007/BF01266324

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  • DOI: https://doi.org/10.1007/BF01266324

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