Summary
Normal mice, mice infected neonatally with LCM virus, and mice from an LCM virus carrier colony have been observed and weighed regularly for up to 600 days. All infected mice were runted. Mice infected neonatally with the WE3 strain of LCM virus showed increased mortality after one year when compared with normal mice, and mice from the LCM virus carrier colony showed increased mortality at all stages of life.
Miscellaneous observations in LCM virus carrier mice are reported, including the occurrence of a muscular dystrophy of unknown aetiology.
The effect of microbial status on the runting, reproduction and mortality of infected mice is discussed, and the need for further study of LCM virus carrier mice is emphasized.
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Mims, C.A. Observations on mice infected congenitally or neonatally with lymphocytic choriomeningitis (LCM) virus. Archiv f Virusforschung 30, 67–74 (1970). https://doi.org/10.1007/BF01262584
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DOI: https://doi.org/10.1007/BF01262584