Summary
Human lymphocytes from donors immunized with poliovirus vaccine and tetanus toxoid supported the replication of poliovirus type 1 when stimulated with these specific antigensin vitro.
The blastogenic response of lymphocytes infected with poliovirus proved to be decreased as measured by partial inhibition of DNA synthesis. The inhibition of DNA synthesis was measured by liquid scintillation and radioautographic methods. The inhibition occured when virus was added up to 4 days after initiation of specific antigenic stimulation. Tuberculin-stimulated lymphocytes from Mantoux positive donors supported the replication of measles virus and poliovirus. The blastogenic response of these infected cells was also inhibited.
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Willems, F.T.C., Vondrovicova, E.L. Replication of poliovirus in human lymphocytes stimulated with specific antigens. Archiv f Virusforschung 30, 31–38 (1970). https://doi.org/10.1007/BF01262580
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DOI: https://doi.org/10.1007/BF01262580