Abstract
Costimulation of anti-CD3-triggered proliferative T-cell responses by type I and type IV collagen and fibronectin was studied in 25 patients with psoriasis and 12 healthy subjects. The stimulation index of anti-CD3-mediated responses in the presence of type I collagen was about half that in the controls. Although the CD3-dependent proliferative response of psoriatic lymphocytes in patients with active widespread plaque psoriasis was reduced by about 50%, costimulatory responses induced by type IV collagen and fibronectin were found to be enhanced in relation to the controls. The degree of costimulation by type IV collagen and fibronectin was related to disease severity. The highest values of the stimulation index were found in patients with a PASI greater than 24, skin involvement of more than 40% of body surface area, and a duration of psoriatic lesions of more than 3 months. The results indicated that in active widespread plaque psoriasis subpopulations of T cells bearing receptors for some extracellular matrix proteins were increased in the peripheral blood. A factor responsible for this phenomenon may be trafficking of T cells through the basement membrane zone of psoriatic lesions, which presumably causes modification of T cell immunological responsiveness after recirculation.
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References
Bos JD (1988) The pathomechanisms of psoriasis; the skin immune system and cyclosporin. Br J Dermatol 118: 141–155
Bjerke JR, Krogh TK, Matre JD (1978) Characterization of mononuclear cell infiltrates in psoriatic lesions. J Invest Dermatol 71: 340–343
Baker BS, Swain AF, Fry L, Valdimarsson H (1984) Epidermal T lymphocytes and HLA-DR expression in psoriasis. Br J Dermatol 110: 555–564
Valdimarsson H, Baker BS, Ingileif I, Fry L (1986) Psoriasis: a disease of abnormal keratinocyte proliferation induced by T lymphocytes. Immunol Today 7: 256–259
Christophers E, Henseler T (1989) Patient subgroups and the inflammatory pattern in psoriasis. Acta Derm Venereol (Stockh) 69 [Suppl 151]: 88–92
Baker BS, Griffiths CE, Lambert S, Powles AV, Leonard JN, Valdimarsson H, Fry L (1987) The effects of cyclosporin A on T lymphocyte and dendritic cell sub-populations in psoriasis. Br J Dermatol 116: 503–510
Cooper KD, Voorhees JJ, Fisher GJ, Chan LS, Gupta AK, Baadsgaard O (1990) Effects of cyclosporine on immunologic mechanisms in psoriasis. J Am Acad Dermatol 23: 1318–1328
Stingl G, Wolff K, Diem E, Baumgartner G, Knapp W (1977) In situ identification of lymphoreticular cells in benign and malignant infiltrates by membrane receptor sites. J Invest Dermatol 69: 231–235
Gottlieb AB, Liftshitz B, Fu SM, Staiano-Coico L, Wand SY, Carter DM (1986) Expression of HLA-DR molecules by keratinocytes and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques. J Exp Med 164: 1013–1028
Nikaein A, Phillips C, Gilbert SC, Savino D, Silverman A, Stone MJ, Menter A (1991) Characterization of skin-infiltrating lymphocytes in patients with psoriasis. J Invest Dermatol 96: 3–9
Prens EP, Benne K, Joost T van, Benner R (1991) The autologous mixed epidermal cell-T lymphocyte reaction is elevated in psoriasis: a crucial role for epidermal HLA-DR+/CD1a- antigen-presenting cells. J Invest Dermatol 96: 880–887
Morganroth GS, Chan LS, Weinstein GD, Voorhees JJ, Cooper KD (1991) Proliferating cells in psoriatic dermis are comprised primarily of T cells, endothelial cells, and factor XIIIa+ perivascular dendritic cells. J Invest Dermatol 96: 333–340
Baadsgaard O, Fox DA, Cooper KD (1988) Human epidermal cells from ultraviolet light-exposed skin preferentially activate autoreactive CD4+2H4+ suppressor-inducer lymphocytes and CD8+ suppressor/cytotoxic lymphocytes. J Immunol 140: 1738–1744
Sanders ME, Makgoba MW, Sharrow SO, Stephany D, Springer TA, Young HA, Shaw S (1988) Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J Immunol 140: 1401–1407
Takeuchi T, Rudd CE, Tanaka S, Rothstein DM, Schlossman SF, Morimoto C (1989) Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system. Eur J Immunol 19: 747–755
Glinski W, Barszcz D, Janczura E, Zarebska Z, Jablonska S (1984) Neutral proteinases and other neutrophil enzymes in psoriasis, and their relation of disease activity. Br J Dermatol 111: 147–154
Buck CA, Horwitz AF (1987) Cell surface receptors for extracellular matrix molecules. Annu Rev Cell Biol 3: 179–205
Baker BS, Powles AV, Lambert S, Valdimarsson H, Fry L (1988) A prospective study of the Koebner reaction and T lymphocytes in uninvolved psoriatic skin. Acta Derm Venereol (Stockh) 68: 430–434
Baadsgaard O, Tong P, Elder JT, Hansen ER, Ho V, Hammerberg C, Lange-Vejlsgaard G, Fox DA, Fisher G, Voorhees JJ, Cooper KD (1990) UM4D4+ (CDw60) T cells are compartmentalized into psoriatic skin and release lymphokines that induce a keratinocyte phenotype expressed in psoriatic lesions. J Invest Dermatol 95: 275–282
Bos JD, Hagenaars C, Das PK, Krieg SR, Voorn WJ, Kapsenberg ML (1989) Predominance of “memory” T cells (CD4+, CDw29+) over “naive” T cells (CD4+, CD45R+) in both normal and diseased human skin. Arch Dermatol Res 281: 24–30
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Glinski, W., Gorski, A., Glinska-Ferenz, M. et al. Excessive costimulation of CD3-dependent lymphocyte response by extracellular matrix proteins in severe widespread psoriasis. Arch Dermatol Res 287, 176–179 (1995). https://doi.org/10.1007/BF01262328
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DOI: https://doi.org/10.1007/BF01262328