Summary
The authors describe an experimental study (14 dogs) and clinical work (24 patients) carried out to evaluate the diagnostic value of tissue pH-measurement as well as of venous lacticemia in chronic arterial occlusion of the lower limbs.
Lactic cannot facilitate any significant data for histological complaints. However, tissue pH measurement can be considered a true reflex of the metabolic state of tissues subjected to ischemia.
Zusammenfassung
Die Verfasser legen eine experimentelle Studie (14 Hunde) und eine klinische Untersuchung (24 Patienten) vor, die den Zweck verfolgt, den diagnostischen Wert der Gewebs-pH-Messung und der Bestimmung des venösen Lactatspiegels bei chronischem arteriellem Verschluß der unteren Gliedmaßen-Arterien zu würdigen.
Die Bestimmung der venösen Lactat-Konzentration erlaubt keine zuverlässige Aussage über den Schweregrad der Ischämie. Dagegen kann das Gewebs-pH als guter Parameter für die Beurteilung der Ischämie angesehen werden.
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Literatur
Carlson, L. A., Pernow, B.: Oxygen utilization and lactic acid formation in den legs at rest and during exercise in normal subjects and in patients with arteriosclerosis obliterans. Acta med. scand.164, 39–52 (1959)
Carlson, L. A., Pernow, B.: Studies on the peripheral circulation and metabolism in man: II. Oxygen utilization and lactate-pyruvate formation in the legs at rest and during exercise in patients with arteriosclerosis obliterans. Acta med. scand.171, 311–323 (1962)
Canossi, G. C., Dardari, M., Cortesi, N., Brunelli, B., Pasquinelli, G.: Anatomie angiographique du chien. Paris: Vigot Frères 1968
Diamant, B., Karlson, J., Saltin, B.: Muscle tissue lactate after maximal exercise in man. Acta physiol. scand.72, 383–384 (1968)
Dmochowski, J. R., Couch, N. P.: Electrometric surface pH of the ischemic kidney and the effect of hypothermia. Surg. Res.6, 45–48 (1966)
Dubuisson, M.: Some chemical and physical aspects of muscle contraction and relaxation. Proc. roy. Soc.137, 63–71 (1950)
Friedman, S. A., Penneys, R.: Lactate-pyruvate studies in ischemic feet. Angiology15, 461–464 (1964)
Fischer, R. A., Yates, F.: Statistical tables for agricultural, biological and medical research. Edinburgh: Oliver Boyd 1953
Glinz, W.: pH-Messung in der Muskulatur. - Ein neues Hilfamittel zur Wahl der Amputationsh6he bei chronischen arteriellen Durchblutungs-Störungen. Langenbecks Arch. Chir.326, 303–322 (1970)
Herrero, L.: Valor de la pH-metria textural en et diagnostico precoz de las lesiones pregangrenosas. Granada: Tesis Doctoral 1974
Hild, R., Brecht, Th., Zolg, H.: Das Laktat/Pyruvat-System als Indikator des Ruhestoffwechsels bei arterieller Verschlußkrankheit der Gliedmaßen. Klin. Wschr.44, 44–47 (1966)
Hlavova, A., Linhart, J., Prerovsky, I., Ganz, V.: Lactate and pyruvate changes in the legs during and after exercise in normal subjects and in patients with femoral arteriocclusion. Clin. Sci. 34, 397–409 (1968)
Hohorst, H. J., Bergmeyer, H. U.: Methoden der enzymatischen Analyse, 1. Aufl. S. 266. Weinheim: Verlag Chemie 1962
Huckabee, W.: Control of concentration gradients of pyruvate and lactate across cell membranes in blood. J. appl. Physiol.9, 163–170 (1956)
Huckabee, W.: Relationships of pyruvate and lactate during anaerobic metabolism. II. Exercise and formation of O2-debt. J. clin. Invest.37, 255–263 (1958)
Jastrzebski, T., Opolski, M., Michalak, J., Stachowicz, J.: Znaczenie angiografii dla ustalenia paziomv odjecia koncezyny w chorobach naczyn obwodowych. Chir. Narzad Ruchu37, 101–106 (1972)
Kuhlmann, R. E., Miller, J. A.: The biochemical changes preceding tissue death in rats. J. Bone Jt Surg. A49, 90–100 (1967)
Lemieux, M. D., Smith, R. N., Couch, N. P., Matey, A. M.: Surface pH and redox potential of skeletal muscle in grade hemorrhage. Surgery65, 457–461 (1969)
Maison, G. L., Orth, 0. S., Lemmer, K. E.: pH-changes in rabbit and human striated muscle after contraction. Amer. J. Physiol.121, 311–324 (1938)
Virkkula, L., Ervasti, O., Sittnikow, K., Perttala, Y.: Two-stage operation for the production of intermittent claudication in dogs. Acts chir. stand.135, 685–687 (1969)
Voegtlin, C., Kahler, H., Fitch, R. H.: The estimation of the hydrogen ion concentration of tissues in living animals by means of the capillary glass electrode. Nat. Inst. Hlth Bull.164, 15–27 (1935)
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Vara-Thorbeck, R., Herrero-Mateo, L. Wert der Gewebs-pH-Messung für die Beurteilung der Ischämie bei arterieller Versehlußkrankheit. Langenbecks Arch Chiv 338, 137–147 (1975). https://doi.org/10.1007/BF01261584
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DOI: https://doi.org/10.1007/BF01261584