Summary
In maintaining the rat, the collagen dressings, Aviderm Amine and Aviderm, are as effective as skin in low bacterial levels in contaminated surgical wounds. In the scald-burn wound in the rat the effect of skin dressing is confirmed. Also, 48 h after collagen dressing in the wound the bacterial contamination was the same as that seen under autograft dressings.
We have elsewhere suggested that skin and some other dressings modify the local host defense by their effect on the accumulated white blood cells. We believe that collagen, as well as some synthetics, can alter the local environment permitting the destruction of invading bacteria by the accumulated white blood cells.
Zusammenfassung
Eigenhaut-, Fremdhaut- und Tierhauttransplantate können die bakterielle Besiedlungsdichte infizierter Wunden (wie z. B. nach Verbrennungen) herabsetzen.
Diese Beobachtungen dienten als Grundlage obenangeführter Untersuchungen.
Auf einen ca. 2 x 2 cm messenden Hautdefekt bei der Ratte wurden 107 Pseudomonas aeruginosa-Keime aufgetropft. Der infizierte Bezirk blieb entweder unbedeckt oder wurde mit Eigenhaut bzw. mit einer eigens präparierten lyophilisierten Ochsenhaut abgedeckt. 48 h danach wurde aus dem infizierten Unterhautgewebe (musculus panniculus) Gewebsproben zur Bestimmung des bakteriellen Infektionsgrades entnommen. Dieser war bei der mit Eigenhaut sowie bei der mit lyophilitisierten Ochsenhaut signifikant geringer als bei der unbedeckten Wunde.
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Herrn Professor Dr. M. Schwaiger zum 65. Geburtstag gewidmet
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Burget, A., Nathan, P., Holder, I.A. et al. The effect of a collagen dressing on contaminated surgical wounds in rats. Langenbecks Arch Chiv 343, 69–73 (1976). https://doi.org/10.1007/BF01261571
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DOI: https://doi.org/10.1007/BF01261571