Zusammenfassung
Die Leberdurchblutung (Xenon133 clearance Methode) sowie der portale Fluß werden nach Vasopressin-Infusion verschiedener Geschwindigkeiten, an cirrhotischen und nicht cirrhotischen Ratten gemessen. Bei langsamer Infusion hatte Vasopressin keine signifikante Wirkung auf den portal-venösen oder auf den Leberblutfluß in cirrhotischen oder nicht cirrhotischen Ratten. Die Infusion von Vasopressin mit einer Geschwindigkeit von 0,08 μU/g KG/min in nicht cirrhotischen Ratten und mit 0,04 bzw. 0,08 μU/g KG/min in cirrhotischen Ratten reduziert den portal venösen aber steigert den Leberblutfluß. Bei höherer Infusionsrate (0,2 μ,U/g KG/min in nicht cirrhotischen Ratten und 0,16 μU/g KG/min in cirrhotischen Ratten) wurde dieser Effekt umgekehrt. Darüber hinaus konnte eine VasopressinInfusion von 0,08 μU/g KG/min den portalen Druck bei cirrhotischen Ratten signifikant senken. Dagegen wurde der portale Druck durch Infusion von 0,16 μU/g KG/min Vasopressin nicht signifikant beeinflußt. Die Bedeutung dieser Befunde für eine mögliche deletäre Wirkung hoher Raten von Vasopressin-Infusion in der Behandlung der portalen Hypertension mit blutenden Oesophagus-Varicen wird diskutiert.
Summary
Liver blood flow (xenon-133 clearance method) and portal venous flow were mesured in cirrhotic and non cirrhotic rats following the infusion of vasopressin at varying rates. At low rates of infusion, vasopressin had no significant effect on portal venous flow or liver blood flow in cirrhotic or noncirrhotic rats. Infusion of vasopressin at a rate of 0.08 μU/g body wt/min in non-cirrhotic rats and 0.04 and 0.08 μU/g body wt/min in cirrhotic rats decreased portal venous flow and increased liver blood flow. At higher rates of infusion (0.2 μU/g body wt/min in non-cirrhotic rats and 0.16 μU/g body wt/min in cirrhotic rats) these effects were reversed. Furthermore, an infusion of 0.08 μU/g body wt/min vasopressin significantly reduced portal pressure in the cirrhotic rat. However, portal pressure was not significantly altered following an infusion of 0.16 μU/g body wt vasopressin. The implications of these findings in relation to the possible deleterious effects of high rates of vasopressin infusion in the management of portal hypertension and bleeding oesophageal varices is discussed.
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Jenkins, S.A., Day, D.W., Mooney, B. et al. The effects of vasopressin on hepatic haemodynamics in the cirrhotic and non-cirrhotic rat. Langenbecks Arch Chiv 365, 135–146 (1985). https://doi.org/10.1007/BF01261140
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DOI: https://doi.org/10.1007/BF01261140