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Äthinyloestradiol und Hepatocarcinogenese. Eine experimentelle Beobachtung

Ethinylostrodiol and hepatic carcinogenesis — an experimental study

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Summary

The influence of ethinylostradiol on hepatocarcinogenesis was investigated in the female Dawley-rat. After 14 weekly gastric instillations of 50 mg diethylnitrosamine/kg and simultaneous administration of diet supplemented with ethinylostradiol 10 mg/l kg diet, 77.8% of the rats developed a hepatocellular carcinom. In contrast, only 31.8% had carcinoma of the liver under similar experimental conditions. The relation of preneoplastic lesions correlated with that of carcinoma induction in both groups. If the results were to be valued on clinical relevance without difficulties a new orientation on surgical indication and transformation of the dignity of benign focal nodular hyperplasia would have to be considered.

Zusammenfassung

Der Einfluß von Äthinyloestradiol in der Hepatocarcinogenese wurde an Dawley-Ratten untersucht. Nach 14wöchentlicher intragastraler Applikation von 50 mg Diäthylnitrosamin/kg entwickelten bei simultaner Verabreichung von Äthinyloestradiol im Futter 77,7% der Tiere ein hepatocelluläres Carcinom. Dagegen wurde nach Behandlung mit Diäthylnitrosamin allein unter ähnlichen experimentellen Bedingungen Leberkrebsinduktionen nur bei 31,8% beobachtet. Präneoplastische Veränderungen korrelierten mit der Relation der Krebsinduktion in beiden Gruppen. Könnte man von den Ergebnissen eine klinische Bedeutung ableiten, müßte eine neue Standortorientierung über chirurgische Indikation und spätere Dignitätsänderung der benignen focalen nodulären Hyperplasien stattfinden.

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Authors and Affiliations

  1. Allgemeinchirurgische Abteilung, Chirurgische Universitätsklinik Hamburg, Martinistraße 52, D-2000, Hamburg 202

    K. de Heer &  H. W. Schreiber

  2. Pathologisches Institut der Universität Hamburg, Martinistraße 52, D-2000, Hamburg 20

    G. Klöppel

Authors
  1. K. de Heer
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  2. G. Klöppel
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  3. H. W. Schreiber
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de Heer, K., Klöppel, G. & Schreiber, H.W. Äthinyloestradiol und Hepatocarcinogenese. Eine experimentelle Beobachtung. Langenbecks Arch Chiv 370, 163–171 (1987). https://doi.org/10.1007/BF01259536

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  • DOI: https://doi.org/10.1007/BF01259536

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