Summary
Tissue cultures of chick embryo fibroblasts are suitable for culturing fowl-, pigeon-, and canary pox viruses. Virus multiplication is accompanied by cytopathogenic effects which allow the titration of these viruses and the differentiation between different virus strains, especially in the fowl pox group.
Continued passages were successful for all strains whereby infectiosity for tissue explants increased. After the 45th passage titres of 10−6 ID50 for fowl pox, 10−5 ID50 for pigeon pox and 10−6,3 ID50 for canary pox strains were obtained.
There is no relationship between the behaviour of pox viruses in explants and their virulence for fowls.
The fowl pox viruses differ in their biological behaviour in explants fundamentally from that of vaccinia virus.
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Mayr, A., Kalcher, K. Vergleichende studien über die züchtung von geflügelpockenviren in der zellkultur. Archiv f Virusforschung 10, 72–102 (1961). https://doi.org/10.1007/BF01258768
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DOI: https://doi.org/10.1007/BF01258768