Summary
The results obtained with two drugs that were found to be effective against influenza virus infection in mice are reported.
The two drugs are C. V. 57455 (4-biphenylylglyoxal bisulfite) and C. V. 58903 (α-oxo-α-(4-biphenylyl)-β-ethoxy-β-(4-carboxy-phenyl) amineethane).
The drugs were active after administration by the subcutaneous, the oral or the nasal routes prior to and partly also 24 hours after, but not 48 hours after instillation of 5 LD50 of the virus.
The drugs were active in low doses providing for an ample margin between the toxic and effective range.
The hemagglutinin titers of the lungs of mice which died despite treatment were lower than those found in the lungs of untreated mice.
The hemagglutinin titers of the lungs of surviving, unaffected, drugtreated mice were very low or undetectable.
The surviving drug-treated mice were resistant to reinfection 2 to 6 weeks later.
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The results were communicated in part to the “Accademia Nazionale dei XL”, Rome-Italy.
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Magrassi, F., Cavallini, G. & Massarani, E. Drugs active against influenza virus infection in mice. Archiv f Virusforschung 10, 19–30 (1961). https://doi.org/10.1007/BF01258765
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DOI: https://doi.org/10.1007/BF01258765