Summary
Cross-neutralization tests of rabbit immune sera against adenoviruses types 1 through 28 revealed a high degree of specificity in many instances. Reciprocal cross-reactions were observed between types 4 and 16, types 15 and 25, types 3 and 7, types 7, 11, and 14, types 11 and 21 and, with some exceptions, between types 1, 2, 5, 6, and 12. The majority of the cross-neutralizations were of low titer. No antigenic difference was found between type 7 and 7a. The antigenically related subgroups correspond well with subgroups of the human adenoviruses, as defined by other criteria.
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Aided by grants of the Deutsche Forschungsgemeinschaft.
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Wigand, R., Bauer, H., Lang, F. et al. Neutralization of the adenoviruses types 1 to 28: Specificity and antigenic relationships. Archiv f Virusforschung 15, 188–199 (1965). https://doi.org/10.1007/BF01257730
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DOI: https://doi.org/10.1007/BF01257730