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Dose-incubation time relationships in virus infected tissue cultures. Theoretical considerations

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Summary

On the basis of the normal distribution of newly formed vaccinia virus plaques upon time found in tissue culture experiments a theoretical analysis was carried out to elucidate expected dose-incubation time relationships. The mean incubation time is continuously increasing with decreasing virus doses. No exact linear relationship was obtained although approximate linearity could be anticipated to exist within certain dose ranges using time directly recorded (t) or the reciprocal of time (1/t) as response variables. As a whole theoretical conclusions agree with experimental observations reported in a separate paper.

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References

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Authors and Affiliations

  1. National Bacteriological Laboratory and the Department of Virus Research, Karolinska Institutet, School of Medicine, Stockholm, Sweden

    J. Åke Espmark & Sven Gard

Authors
  1. J. Åke Espmark
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  2. Sven Gard
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Espmark, J.Å., Gard, S. Dose-incubation time relationships in virus infected tissue cultures. Theoretical considerations. Archiv f Virusforschung 15, 137–150 (1965). https://doi.org/10.1007/BF01257725

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  • DOI: https://doi.org/10.1007/BF01257725

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