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Das Verhalten der Plasmakatecholamine nach Bauchoperationen beim Menschen

Plasma catecholamine levels after abdominal operations in man

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Summary

In 13 patients (7 women, 6 men, average age 61 year), who under Went a major abdominal operation and whose postoperative course was uncomplicated, the plasma catecholamines (noradrenaline and adrenaline) were measured one day before operation, 3 to 5 hours after operation as well as on the first and third postoperative day. The heart rate, central venous and arterial pressure, hemoglobin and body temperature were determined simultaneously.

  1. 1.

    In the first postoperative phase total catecholamine mounts to nearly twice the initial value. However, it rises only slightly towards the first postoperative day. On the third postoperative day there is a decreasing tendency.

  2. 2.

    Noradrenaline rises already three to five hours postoperatively to its highest mean level, while adrenaline reaches its highest mean level on the first postoperative day.

  3. 3.

    Heart rate rises from an average 77/min to 94/min at the first postoperative day. Central venous pressure decreases toward the first postoperative day by an average of 1 mmHg, in order to reach its initial value on the third day. Arterial pressure, hemoglobin and body temperature stay unchanged during the period of examination.

  4. 4.

    There is a certain quantitative relation between the augmentation of total catecholamine and heart rate.

These findings together with relevant literature are discussed and probable causes for raised sympathico-adrenergic activities in the early postoperative phase are demonstrated.

Zusammenfassung

Bei 13 Patienten (7 Frauen, 6 Manner, mittleres Lebensalter 61 Jahre), die sich einer größeren Bauchoperation unterziehen mußten und deren postoperativer Verlauf klinisch unkompliziert war, wurde am Tage vor, 3 bis 5 Std nach Operationsende Bowie am 1. und 3. postoperativen Tage der Plasmakatechol aminspiegel gemessen. Gleichzeitig warden die Herzfrequenz, der zentralvenöse und arterielle Druck, der Hämoglobingehalt Bowie die Körpertemperatur bestimmt. 1. Der Gesamtplasmakatecholamingehalt ist in den ersten postoperativen Std auf fast das Doppelte des mittleren Ausgangwertes angestiegen und nimmt zum

  1. 1.

    Tage hin noch gering zu. Am 3. Tage besteht eine rückläufige Tendenz.

  2. 2.

    Das Noradrenalin erreicht bereits 3 his 5 Std nach Operationsende, das Adrenalin am 1. postoperativen Tage seinen höchsten mittleren Wert.

  3. 3.

    Die Herzfrequenz steigt von durchschnittlich 77/min auf 85/min bei der ersten postoperativen Messung und auf 94/min am 1. postoperativen Tage. Der zentrale Venendruck nimmt zum 1. Tage hin um durchschnittlich 1 mmHg ab, um am

  4. 3.

    Tage den Ausgangswert zu erreichen. Arterieller Druck, Hämoglobingehalt und Körpertemperatur ändern sich fiber die Untersuchungszeit nicht.

  5. 4.

    Zwischen dem Anstieg der Gesamtkatecholamine und dem der Herzfrequenz besteht eine gewisse quantitative Beziehung.

Die Befunde werden zusammen mit der Literatur diskutiert und mögliche Ur sachen für die erhöhte sympathicoadrenerge Aktivität in der frühen postoperativen Phase aufgezeigt.

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Authors and Affiliations

  1. Klinikum Westend der FU, Chirurgische Univ.-Klinik u. Poliklinik im, 19 Spandauer Damm 130, D-1000, Berlin

    R. Eisele, F. W. Lohmann, D. Kötter & M. Nasseri

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  1. R. Eisele
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  2. F. W. Lohmann
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  3. D. Kötter
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  4. M. Nasseri
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Eisele, R., Lohmann, F.W., Kötter, D. et al. Das Verhalten der Plasmakatecholamine nach Bauchoperationen beim Menschen. Langenbecks Arch Chiv 336, 103–113 (1974). https://doi.org/10.1007/BF01257434

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  • DOI: https://doi.org/10.1007/BF01257434

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