Journal of Neural Transmission

, Volume 64, Issue 3–4, pp 285–293 | Cite as

Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockersin vitro

  • W. Ilias
  • K. Steinbereithner
Original Papers

Summary

The calcium channel blockers verapamil, methoxyverapamil, diltiazem, and nisoldipine have been tested for interactions with the nondepolarizing muscle relaxant pancuronium bromide by using the indirectly stimulatedin vitro preparation of the rat hemidiaphragm. Dose response curves of each calcium channel blocker, pancuronium bromide, and combinations of both were determined.

Each of the four calcium channel blocking drugs showed agonistic interaction in potentiating pancuronium induced neuromuscular blockade.

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • W. Ilias
    • 1
  • K. Steinbereithner
    • 1
  1. 1.L. Boltzmann-Institut für Experimentelle Anaesthesiologie und Intensivmedizinische ForschungKlinik für Anaesthesie und Allgemeine Intensivmedizin der Universität WienÖsterreich

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