Journal of Neural Transmission

, Volume 59, Issue 4, pp 257–264 | Cite as

3H-imipramine and3H-cyano-imipramine binding in rat brain tissue: Effect of long-term antidepressant administration

  • C. Gentsch
  • M. Lichtsteiner
  • H. Feer
Original Papers


3H-imipramine and3H-cyano-imipramine binding was determined in brain homogenates of rats which had been treated for 21 days with imipramine or desimipramine. When compared to control animals, long-term administration of these antidepressants did not induce any alteration in the maximal number of3H-imipramine or3H-cyano-imipramine binding sites. However, a transient increase in the apparent dissociation constant was observed. Such findings are discussed in respect to previous studies, which have been highly contraversial.


Public Health Binding Site Brain Tissue Dissociation Constant Imipramine 
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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • C. Gentsch
    • 1
  • M. Lichtsteiner
    • 1
  • H. Feer
    • 1
  1. 1.Biochemical LaboratoryPsychiatric University Clinic BasleSwitzerland

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