Summary
3H-imipramine and3H-cyano-imipramine binding was determined in brain homogenates of rats which had been treated for 21 days with imipramine or desimipramine. When compared to control animals, long-term administration of these antidepressants did not induce any alteration in the maximal number of3H-imipramine or3H-cyano-imipramine binding sites. However, a transient increase in the apparent dissociation constant was observed. Such findings are discussed in respect to previous studies, which have been highly contraversial.
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Gentsch, C., Lichtsteiner, M. & Feer, H. 3H-imipramine and3H-cyano-imipramine binding in rat brain tissue: Effect of long-term antidepressant administration. J. Neural Transmission 59, 257–264 (1984). https://doi.org/10.1007/BF01255595
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DOI: https://doi.org/10.1007/BF01255595