Radiation and Environmental Biophysics

, Volume 33, Issue 1, pp 63–68 | Cite as

The question of threshold doses for radiation damage: Malformations induced by radiation exposure of unicellular or multicellular preimplantation stages of the mouse

  • W. -U. Müller
  • C. Streffer
  • S. Pampfer


Mouse embryos of the one-cell stage or the 32- to 64-cell stage were exposed to various X-ray doses (one-cell stage: 0.25-2 Gy; 32- to 64-cell stage: 1–3 Gy). It turned out that the shape of the dose-response curves is statistically compatible with the assumption derived from biological considerations that there is no threshold for radiation-induced malformations in the case of the exposure of one-cell embryos, whereas there is a threshold dose (close to 1 Gy) in the case of the exposure of 32- to 64-cell embryos.


Radiation Radiation Exposure Environmental Physic Mouse Embryo Radiation Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Hulse EV, Mole RH (1982) Reflections on the terms stochastic and non-stochastic as currently used in radiological protection. Br J Radiol 55:321–324Google Scholar
  2. ICRP Publication 26 (1977) Recommendations of the International Commission on Radiological Protection. Ann ICRP 1Google Scholar
  3. ICRP Publication 30 (1979) Limits for intakes of radionuclides by workers. Ann ICRP 2Google Scholar
  4. ICRP Publication 60 (1991) 1990 recommendations of the International Commission on Radiological Protection. Ann ICRP 21Google Scholar
  5. Kelly SJ (1975) Studies of the potency of the early cleavage blastomeres of the mouse. In: Balls M, Wild AE (eds) The early development of mammals. Cambridge University Press, Cambridge, UK, pp 97–105Google Scholar
  6. Müller W-U, Streffer C (1990) Lethal and teratogenic effects after exposure to X-rays at various times of early murine gestation. Teratology 42:643–650Google Scholar
  7. Pampfer S, Streffer C (1988) Prenatal death and malformations after irradiation of mouse zygotes with neutrons or X-rays. Teratology 37:599–607Google Scholar
  8. Tarkowski AK (1959) Experiments on the development of isolated blastomeres of mouse eggs. Nature 184:1286–1287Google Scholar
  9. Willadsen SM (1989) Cloning of sheep and cow embryos. Genome 31:956–962Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • W. -U. Müller
    • 1
  • C. Streffer
    • 1
  • S. Pampfer
    • 1
  1. 1.Institut für Medizinische StrahlenbiologieUniversitätsklinikum EssenEssenGermany

Personalised recommendations