Summary
In the present work, the effects of 3-acetylpyridine (3-AP) on the adrenal medulla were investigated for biochemical and morphological changes.
Adrenaline- and noradrenaline-storing cells treated with 3-AP one day previously had lost almost all their granules. A large number of lipoid droplets appeared in the cytoplasm. At the same time, the concentrations of adrenaline and noradrenaline cells were significantly decreased below control values (P< 0.01). However, these significant changes were ameliorated 19 days after 3-AP treatment. Morphologically and biochemically, the adrenaline- and noradrenaline-storing cells had recovered completely at 35 days.
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Imahayashi, T., Shimada, M. & Ozaki, H.S. Effects of 3-acetylpyridine on the adrenal medulla of the mouse. J. Neural Transmission 60, 45–55 (1984). https://doi.org/10.1007/BF01254764
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DOI: https://doi.org/10.1007/BF01254764