Summary
Hemadsorption of sensitized sheep erythrocytes by herpes simplex virus (HSV) infected HeLa cells occurs independently of virus multiplication. When hemadsorption of HSV infected HeLa and rabbit kidney (RK) cells was compared with erythro-phagocytosis by rabbit macrophages, both the HSV infected cell cultures and the uninfected rabbit macrophages behaved exactly the same. This hemadsorption could be inhibited in both cell systems with homologous anti-host serum, whereas anti-HSV serum only inhibited the hemadsorption in HSV infected HeLa and RK cells. Some anti-metabolic agents capable of inhibiting the erythro-phagocytosis in macrophages could also inhibit the herpesvirus-induced hemadsorption.
These results indicated that the infection with HSV induces a modification in the host cell membrane and endowing the cells with a hemadsorbing ability similar to that of macrophages.
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Shimizu, Y. Modification of host cell membrane after herpes simplex virus infection. Archiv f Virusforschung 33, 338–346 (1971). https://doi.org/10.1007/BF01254690
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DOI: https://doi.org/10.1007/BF01254690