Summary
Rabbits immunized with measles- and mumps viruses grown in monkey kidney cells and chick embryo fibroblasts and with their water- and organic solvent fractions obtained by Tween-ether treatment developed immediate type skin hyperreactivity (Arthus phenomenon-like) to challenge with the complete viruses and calf serum, but not to challenge with tissue antigens prepared in the absence of calf serum. The skin reaction in animals immunized with ether fractions was stronger than in animals immunized with water fractions or complete virus, respectively. The intensity of individual skin reactions in each animal was better correlated to the presence of precipitating antibody against calf serum or a component thereof than to the HI titer against the viruses used for immunization.
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The seriological tests for measles and mumps were supported by the Bundesminister für Jugend, Familie und Gesundheit, Bonn, BRD.
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Bonin, O., Schmidt, I., Schmidt, K. et al. Arthus phenomenon like skin reaction and antibody pattern in rabbits immunized with various myxovirus fractions. Archiv f Virusforschung 33, 211–224 (1971). https://doi.org/10.1007/BF01254677
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DOI: https://doi.org/10.1007/BF01254677