Archiv für die gesamte Virusforschung

, Volume 31, Issue 3–4, pp 191–195 | Cite as

Effect of statolon on lactate dehydrogenase virus infection in mice

  • Charles G. CrispensJr.


Statolon, an interferon inducer, was found to be effective in inhibiting the multiplication of the lactate dehydrogenase (LDH) virus in mice. Under the conditions tested, optimal protection was achieved by a single intraperitoneal injection (4.5 mg/20 to 22 g mouse) given 6 to 12 hours prior to the challenge. When various dilutions of the virus were compared, a relationship was observed between the original dose and the loss in titer at 24 hours. The results are interpreted as evidence supporting the view that interferon plays a role in the abrupt suppression of the initial high rate of LDH virus replication.


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  1. 1.
    Notkins, A. L.: Lactic dehydrogenase virus. Bact. Rev.29, 143–160 (1965).PubMedGoogle Scholar
  2. 2.
    Riley, V.: Lactate dehydrogenase in the normal and malignant state in mice and the influence of a benign enzyme-elevating virus. Methods in Cancer Research, pp. 493–618, ed. by H. Busch. New York: Academic Press, Volume IV, 1968.Google Scholar
  3. 3.
    Notkins, A. L., andS. J. Shochat: Studies on the multiplication and the properties of the lactic dehydrogenase agent. J. exp. Med.117, 735–747 (1963).PubMedGoogle Scholar
  4. 4.
    Stark, D. M., andC. G. Crispens, Jr.: Studies on the multiplication of lactic dehydrogenase elevating agents. Experientia20, 270 (1965).Google Scholar
  5. 5.
    Rowson, K. E. K., B. W. J. Mahy, andM. Bendinelli: Riley virus neutralizing activity in the plasma of infected mice with persistent viraemia. Virology28, 775–778 (1966).PubMedGoogle Scholar
  6. 6.
    Baron, S., H. G. Dubuy, C. E. Buckler, andM. L. Johnson: Relationship of interferon production to virus growthin vivo. Proc. Soc. exp. Biol. (N.Y.)117, 338–341 (1964).Google Scholar
  7. 7.
    Dubuy, H. G., andM. L. Johnson: Some properties of the lactic dehydrogenase agent of mice. J. exp. Med.122, 587–600 (1965).PubMedGoogle Scholar
  8. 8.
    Evans, E., andV. Riley: Circulating interferon in mice infected with the lactate dehydrogenase-elevating virus. J. gen. Virol.3, 449–452 (1968).PubMedGoogle Scholar
  9. 9.
    Crispens, C. G., Jr.: Effect of actinomycin D on mice infected with the lactate dehydrogenase virus. Experientia22, 823 (1966).PubMedGoogle Scholar
  10. 10.
    Kleinschmidt, W. J., andE. B. Murphy: Interferon induction with statolon in the intact animal. Bact. Rev.31, 132–137 (1967).PubMedGoogle Scholar
  11. 11.
    Crispens, C. G., Jr.: On the transmission of the lactic dehydrogenase agent from mother to offspring. J. nat. Cancer Inst.34, 331–336 (1965).PubMedGoogle Scholar
  12. 12.
    Crispens, C. G., Jr.: Effect of thymectomy on mice infected with the lactate dehydrogenase agent. J. nat. Cancer Inst.36, 81–87 (1966).PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • Charles G. CrispensJr.
    • 1
  1. 1.Department of AnatomyUniversity of Sherbrooke Faculty of MedicineSherbrookeCanada

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