Effect of statolon on lactate dehydrogenase virus infection in mice
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Statolon, an interferon inducer, was found to be effective in inhibiting the multiplication of the lactate dehydrogenase (LDH) virus in mice. Under the conditions tested, optimal protection was achieved by a single intraperitoneal injection (4.5 mg/20 to 22 g mouse) given 6 to 12 hours prior to the challenge. When various dilutions of the virus were compared, a relationship was observed between the original dose and the loss in titer at 24 hours. The results are interpreted as evidence supporting the view that interferon plays a role in the abrupt suppression of the initial high rate of LDH virus replication.
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- 2.Riley, V.: Lactate dehydrogenase in the normal and malignant state in mice and the influence of a benign enzyme-elevating virus. Methods in Cancer Research, pp. 493–618, ed. by H. Busch. New York: Academic Press, Volume IV, 1968.Google Scholar
- 4.Stark, D. M., andC. G. Crispens, Jr.: Studies on the multiplication of lactic dehydrogenase elevating agents. Experientia20, 270 (1965).Google Scholar
- 6.Baron, S., H. G. Dubuy, C. E. Buckler, andM. L. Johnson: Relationship of interferon production to virus growthin vivo. Proc. Soc. exp. Biol. (N.Y.)117, 338–341 (1964).Google Scholar