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Action du chlorhydrate de N′N′ anhydro-Bis (β-hydroxy-ethyl) Biguanide (ABOB) sur le développement du virus de l'herpès en culture de tissu

Action of compound ABOB on the development of herpesvirus in baboon kidney cell cultures

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Résumé

Le produit ABOB [Chlorhydrate de N′N′ anhydro-bis (β-hydroxy-ethyl) biguanide] exerce une action inhibitrice réversible sur le développement du virus de l'Herpès dans des cellules en culture de rein de babouin. Sa faible action sur la synthèse d'ADN viral et la très forte inhibition du développement viral qu'il provoque à partir de la 10ème heure après inoculation suggèrent qu'il pourrait conduire à la formation de protéines structurales non fonctionnelles.

Summary

The compound ABOB [N′N′ anhydrobis (β-hydroxyethyl) biguanide hydrochloride] has a reversible action on the development of herpesvirus in baboon kidney cell cultures. Its weak action on the viral DNA synthesis and the strong inhibition it provokes on the viral development from the 10th hour after inoculation suggests that it could lead to the formation of non-functional structural proteins.

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Author notes

  1. R. Vilaginès (Attaché de Recherche de l'I.N.S.E.R.M.)

    Present address: Roche Institute of Molecular Biology, 07110, Nutley, NJ, USA

Authors and Affiliations

  1. Institut de Perfectionnement des Médecins (I.S.U.L.), Sofia, Bulgarie

    A. Galabov (Chaire de Virologie)

  2. Service des Virus, Institut Pasteur, Paris

    R. Vilaginès (Attaché de Recherche de l'I.N.S.E.R.M.)

Authors
  1. A. Galabov
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  2. R. Vilaginès
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Travail effectué au Service des Virus (Prof. P. Lépine) de l'Institut Pasteur de Paris.

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Galabov, A., Vilaginès, R. Action du chlorhydrate de N′N′ anhydro-Bis (β-hydroxy-ethyl) Biguanide (ABOB) sur le développement du virus de l'herpès en culture de tissu. Archiv f Virusforschung 31, 183–190 (1970). https://doi.org/10.1007/BF01253750

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  • DOI: https://doi.org/10.1007/BF01253750

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