Summary
DEAE-dextran, when added to the blood-virus meal, enhances the infection ofAedes aegypti by Sindbis-1, Sindbis-s, Semliki Forest and West Nile viruses through feeding.
No such effect has been observed with CEE, neurotropic and 17D yellow fever viruses, nor in the systemAnopheles stephensi — Sindbis virus. The mode of action of DEAE-dextran is discussed and evidence is presented that thereby those cells (probably stomach cells) are involved where the virus first attaches, penetrates and multiplies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chamberlain, R. W., andW. D. Sudia: Mechanisms of transmission of viruses by mosquitoes. Ann. Rev. Entomol.6, 371–390 (1961).
Collins, W. E., and A. J.Harrison: Studies on the laboratory transmission of group A arboviruses by anopheline mosquitoes. Proc. 52nd Meeting New Jersey Mosq. exterm. Ass. Atlantic City N. J. 182–186 (1965).
Craighead, Y. E.: Effect of polycations on growth and dissemination of the encephalomyocarditis virus in mice. J. Virol.1, 988–995 (1968).
Fayet, M. T.: Augmentation du pouvoir infectant de l'acide ribonucléique du virus de la fièvre aphteuse par addition de diethyl-amino-ethyl dextran. C. R. Acad. Sci. (Paris)264, 783–784 (1967).
La Motte: Japanese B encephalitis virus in the organs of infected mosquitoes. Amer. J. Hyg.72, 73–78 (1960).
Mussgay, M.: Growth cycle of arboviruses in vertebrate and arthropod cells. Progr. med. Virol.6, 193–267 (1964).
Pagano, J. S., andA. Vaheri: Enhancement of infectivity of poliovirus RNA with diaethyl-amino-ethyl dextran. Arch. ges. Virusforsch.17, 456–464 (1965).
Pagano, J. S., H. H. McCutchan, andA. Vaheri: Factors influencing the enhancement of the infectivity of poliovirus ribonucleic acid by diethyl-amino-ethyl dextran. J. Virol.1, 891–897 (1967).
Pattyn, S. R., andL. de Vleesschauwer: Study of two plaque variants of Middelburg (arbogroup A) arbovirus. Arch. ges. Virusforsch.19, 176–189 (1966).
Pattyn, S. R., andL. de Vleesschauwer: Plaque production with group A arboviruses. I. Influence of DEAE-dextran on plaques under agar and agarose. Plaque production under carboxymethylcellulose overlays. Acta virol.11, 305–311 (1967).
Pattyn, S. R., andL. de Vleesschauwer: The multiplication of Middelburg -s and -l plaque viruses inAedes aegypti mosquitoes. Acta virol.12, 347–354 (1968a).
Pattyn, S. R., andL. de Vleesschauwer: Plaque production by group A arboviruses. II. Enhancing effect of DEAE-dextran on plaque numbers in chick embryo cells. Acta virol.13, 26–33 (1968b).
Pattyn, S. R., andL. de Vleesschauwer: Behaviour of l and s plaque variants of Sindbis and Western equine encephalitis viruses inAedes aegypti. Ann. Soc. belge Méd. trop.49, 63–68 (1969).
Takemoto, K. K.: Plaque mutants of animal viruses. Progr. med. Virol.8, 314–348 (1966).
Verlinde, J. D., H. A. E. Van Tongeren, S. R. Pattyn, andA. R. Rosenzweig: Virus meningo-encephalitis in Austria. Bull. Wld Hlth Org.12, 565–579 (1955).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pattyn, S.R., De Vleesschauwer, L. The enhancing effect of diethyl-amino-ethyl dextran on the infectivity of arboviruses for Aedes aegypti. Archiv f Virusforschung 31, 175–182 (1970). https://doi.org/10.1007/BF01253749
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01253749