Journal of Neural Transmission

, Volume 70, Issue 3–4, pp 377–381

Increasedα2;-adrenoceptor density in the frontal cortex of depressed suicide victims

  • J. J. Meana
  • J. A. García-Sevilla
Short Note

DOI: 10.1007/BF01253612

Cite this article as:
Meana, J.J. & García-Sevilla, J.A. J. Neural Transmission (1987) 70: 377. doi:10.1007/BF01253612


The density of brainα2-adrenoceptors, quantitated by means of the binding of the agonist [3H]clonidine, was studied in post-mortem cortical membranes of matched control subjects and depressed suicide victims. In the depressed suicide group, the specific high affinity binding of [3H]clonidine was found to be significantly increased (Bmax, 72% greater; p<0.01) without significant changes in the KD value for the radioligand. These preliminary results indicate thatα2-adrenoceptor density in the high affinity stateα2H) is increased in the brain of depressed patients and add strong support to the hypothesis that endogenous depression is related to supersensitiveα2-adrenoceptors.

Key words

α2-Adrenoceptors human brain suicide depression 

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • J. J. Meana
    • 1
  • J. A. García-Sevilla
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of the Basque CountryLeioaSpain

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