Journal of Neural Transmission

, Volume 70, Issue 3–4, pp 377–381 | Cite as

Increasedα2;-adrenoceptor density in the frontal cortex of depressed suicide victims

  • J. J. Meana
  • J. A. García-Sevilla
Short Note


The density of brainα2-adrenoceptors, quantitated by means of the binding of the agonist [3H]clonidine, was studied in post-mortem cortical membranes of matched control subjects and depressed suicide victims. In the depressed suicide group, the specific high affinity binding of [3H]clonidine was found to be significantly increased (Bmax, 72% greater; p<0.01) without significant changes in the KD value for the radioligand. These preliminary results indicate thatα2-adrenoceptor density in the high affinity stateα2H) is increased in the brain of depressed patients and add strong support to the hypothesis that endogenous depression is related to supersensitiveα2-adrenoceptors.

Key words

α2-Adrenoceptors human brain suicide depression 


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  1. Asakura M, Tsukamoto T, Imafuku J, Matsui H, Ino M, Hasegawa K (1985) Quantitative analysis of rat brainα 2-receptors discriminated by [3H]clonidine and [3H]rauwolscine. Eur J Pharmacol 106: 141–147Google Scholar
  2. Cash R, Raisman R, Ruberg M, Agid Y (1985) Adrenergic receptors in frontal cortex in human brain. Eur J Pharmacol 108: 225–232PubMedGoogle Scholar
  3. Crow TJ, Cross AJ, Cooper SJ, Deakin JFW, Ferrier IN, Johnson JA, Joseph MH, Owen F, Poulter M, Lofthouse R, Corsellis JAN, Chambers DR, Blessed G, Perry EK, Perry RH, Tomlinson BE (1984) Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology 23: 1561–1569PubMedGoogle Scholar
  4. Garía-Sevilla JA, Fuster MJ (1986) Labelling of human plateletα 2-adrenoceptors with the full agonist [3H](−)adrenaline. Eur J Pharmacol 124: 31–41PubMedGoogle Scholar
  5. García-Sevilla JA, Guimón J, García-Vallejo P, Fuster MJ (1986) Biochemical and functional evidence of supersensitive plateletα 2-adrenoceptors in major affective disorder. Arch Gen Psychiatry 43: 51–57PubMedGoogle Scholar
  6. García-Sevilla JA, Udina C, Alvarez E, Casas M (1987) Enhanced binding of [3H](−)adrenaline to platelets of depressed patients with melancholia: Effect of long-term clomipramine treatment. Acta Psychiatr Scand 75: 150–157PubMedGoogle Scholar
  7. García-Sevilla JA, Zis AP, Hollingsworth PJ, Greden JF, Smith CB (1981) Plateletα 2-adrenergic receptors in major depressive disorder. Arch Gen Psychiatry 38: 1327–1333PubMedGoogle Scholar
  8. Kafka MS, Paul SM (1986) Plateletα 2-adrenergic receptors in depression. Arch Gen Psychiatry 43: 91–95PubMedGoogle Scholar
  9. Linkowski P, Maertelaer V de, Mendlewicz J (1985) Suicidal behaviour in major depressive illness. Acta Psychiatr Scand 72: 233–238PubMedGoogle Scholar
  10. Piletz JE, Schubert DSP, Halaris A (1986) Evaluation of studies on platelet alpha2-adrenoreceptors in depressive illness. Life Sci 39: 1589–1616PubMedGoogle Scholar
  11. Schildkraut JJ (1965) The catecholamine hypothesis of affective disorders: A review of supporting evidence. Am J Psychiatry 122: 509–522PubMedGoogle Scholar
  12. Smith CB, García-Sevilla JA, Hollingsworth PJ (1981)α 2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant treatment. Brain Res 210: 413–418PubMedGoogle Scholar
  13. U'Prichard DC (1984) Biochemical characteristics and regulation of brainα 2-adrenoceptors. In: Salama AI (ed) Presynaptic modulation of post-synaptic receptors in mental diseases. Ann NY Acad Sci vol 430, New York, pp 55–75Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • J. J. Meana
    • 1
  • J. A. García-Sevilla
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of the Basque CountryLeioaSpain

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