Increasedα2;-adrenoceptor density in the frontal cortex of depressed suicide victims
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The density of brainα2-adrenoceptors, quantitated by means of the binding of the agonist [3H]clonidine, was studied in post-mortem cortical membranes of matched control subjects and depressed suicide victims. In the depressed suicide group, the specific high affinity binding of [3H]clonidine was found to be significantly increased (Bmax, 72% greater; p<0.01) without significant changes in the KD value for the radioligand. These preliminary results indicate thatα2-adrenoceptor density in the high affinity stateα2H) is increased in the brain of depressed patients and add strong support to the hypothesis that endogenous depression is related to supersensitiveα2-adrenoceptors.
Key wordsα2-Adrenoceptors human brain suicide depression
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- Asakura M, Tsukamoto T, Imafuku J, Matsui H, Ino M, Hasegawa K (1985) Quantitative analysis of rat brainα 2-receptors discriminated by [3H]clonidine and [3H]rauwolscine. Eur J Pharmacol 106: 141–147Google Scholar
- Crow TJ, Cross AJ, Cooper SJ, Deakin JFW, Ferrier IN, Johnson JA, Joseph MH, Owen F, Poulter M, Lofthouse R, Corsellis JAN, Chambers DR, Blessed G, Perry EK, Perry RH, Tomlinson BE (1984) Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology 23: 1561–1569PubMedGoogle Scholar
- U'Prichard DC (1984) Biochemical characteristics and regulation of brainα 2-adrenoceptors. In: Salama AI (ed) Presynaptic modulation of post-synaptic receptors in mental diseases. Ann NY Acad Sci vol 430, New York, pp 55–75Google Scholar