Advertisement

Distribution of amygdala input to the nucleus accumbens septi: An electrophysiological investigation

  • C. W. Callaway
  • R. L. Hakan
  • S. J. Henriksen
Full Papers

Summary

The nucleus accumbens septi (NAS) receives afferent input from the amygdala via the stria terminalis and from the hippocampus via the fimbria. Extracellular recordings from 196 NAS neurons in halothane-anesthetized rats revealed heterogeneous response patterns following stimulation of the amygdala. The observation that 30% of anterior NAS units but only 16% of posterior NAS units were responsive to amygdala stimulation suggested a topographical arrangement of amygdala efferents. Comparing the effects of amygdala and fimbria stimulation revealed that the two afferent pathways converge onto individual NAS neurons, but that the two sites of stimulation can differentially influence other neurons. The present results clarify the topographical distribution of amygdala input to the NAS, confirm that inputs from two limbic structures are integrated within the NAS, and further illustrate the electrophysiological heterogeneity of NAS neurons.

Keywords

Amygdala hippocampus nucleus accumbens electrophysiology 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Christie MJ, Summer RJ, Stephenson JA (1985) Excitatory amino acid projections to the nucleus accumbens septi in the rat: a retrograde transport study using d[3H] aspartate and [3H]GABA. Neuroscience 22: 425–439Google Scholar
  2. Conrad LCA, Pfaff DW (1976) Autoradiographic tracing of nucleus accumbens efferents in the rat. Brain Res 113: 589–596PubMedGoogle Scholar
  3. DeFranc JF, Marchand JE, Stanley JC, Sikes RW, Chronister RB (1980) Convergence of excitatory amygdaloid and hippocampal input in the nucleus accumbens septi. Brain Res 185: 183–186PubMedGoogle Scholar
  4. DeFrance JF, Sikes RW, Chronister RB (1985) Dopamine action in the nucleus accumbens. J Neurohysiol 54: 1568–1577Google Scholar
  5. De Olmos JS, Ingram WR (1972) The projection field of the stria terminalis in the rat brain. An experimental study. J Comp Neurol 146: 303–334PubMedGoogle Scholar
  6. Groenwegen HJ, Becker NEHM, Lohan AHM (1980) Subcortical afferents of the nucleus accumbens septi in the rat: studies using retrograde axonal transport of horseradish peroxidase and bisbenzimid. Neuroscience 5: 1903–1916PubMedGoogle Scholar
  7. Groves PM (1983) A theory of the functional organization of the neostriatum and the neostriatal control of voluntary movement. Brain Res Rev 5: 109–132Google Scholar
  8. Hakan RL, Henriksen SJ (1987) Systemic opiate administration has heterogenous effects on activity recorded from nucleus accumbens neurons in vivo. Neurosci Lett 83: 307–312PubMedGoogle Scholar
  9. Heimer L, Wilson RB (1975) The subcortical projections of the allocortex: similarities in the neural associations of the hippocampus, the piriform cortex and the neocortex. In: Santini M (ed) Golgi Centennial Symposium, Proceedings. Raven Press, New York, pp 177–193Google Scholar
  10. Herkenham M, Moon-Edley S, Stuart J (1987) Cell clusters in the nucleus accumbens of the rat, and the mosaic relationship of opiate receptors, acetylcholinesterase and subcortical afferent terminations. Neuroscience 11: 561–593Google Scholar
  11. Ito N, Ishida H, Miyakawa F, Naito H (1974) Microelectrode study of projections from the amygdaloid complex of the nucleus accumbens in the cat. Brain Res 67: 338–341PubMedGoogle Scholar
  12. Kelley AE, Domesick VB (1982) The distribution of projections from the hippocampal formation to the nucleus accumbens in the rat: an anterograde and retrograde horseradish peroxidase study. Neuroscience 7: 2321–2335PubMedGoogle Scholar
  13. Kelley AE, Domesick VB, Nauta WJH (1982) The amygdalostriatal projection in the rat — an anatomical study by anterograde and retrograde tracing methods. Neuroscience 7: 615–630PubMedGoogle Scholar
  14. Kretteck JE, Price JL (1978) Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat. J Comp Neurol 178: 225–254PubMedGoogle Scholar
  15. Mogenson GJ (1987) Limbic-motor integration. Progr Psychobiol Physiol Psychol 12: 117–170Google Scholar
  16. Mogenson GJ, Swanson LW, Wu M (1983) Neural projections from the nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat. J Neurosci 3: 189–202PubMedGoogle Scholar
  17. Newman R, Winans SS (1980) An experimental study of the ventral striatum of the golden hamster. I. Neuronal connections of the nucleus accumbens. J Comp Neurol 191: 167–192PubMedGoogle Scholar
  18. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic, New YorkGoogle Scholar
  19. Phillipson OT, Griffiths AC (1985) The topographic order of inputs to nucleus accumbens in the rat. Neuroscience 16: 275–296PubMedGoogle Scholar
  20. Ragsdale CW, Graybiel AM (1988) Fibers from the basolateral nucleus of the amygdala selectively innervate striosomes in the caudate nucleus of the cat. J Comp Neurol 269: 502–522Google Scholar
  21. Renaud LP, Hopkins DA (1977) Amygdala afferents from the mediobasal hypothalamus: an electrophysiological and neuroanatomical study in the rat. Brain Res 121: 210–213Google Scholar
  22. Swanson LW, Cowan WM (1975) A note on the connections and development of the nucleus accumbens. Brain Res 92: 324–330PubMedGoogle Scholar
  23. Swerdlow NR, Koob GF (1987) Dopamine, schizophrenia, mania and depression: towards a unified hypothesis of cortico-striato-pallido-thalamic function. Behav Brain Sci 10: 197–245Google Scholar
  24. Williams DJ, Crossman AR, Slater P (1977) The efferent projections of the nucleus accumbens in the rat. Brain Res 130: 217–227PubMedGoogle Scholar
  25. Wise R (1987) The role of reward pathways in the development of drug dependence. Pharmacol Ther 35: 227–263PubMedGoogle Scholar
  26. Yim CY, Mogenson GJ (1982) Response of nucleus accumbens neurons to amygdala stimulation and its modification by dopamine. Brain Res 239: 401–415PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • C. W. Callaway
    • 1
  • R. L. Hakan
    • 1
  • S. J. Henriksen
    • 1
  1. 1.Department of Preclinical NeurosciencesResearch Institute of Scripps ClinicLa JollaUSA

Personalised recommendations