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Genetic studies of respiratory syneytial virus temperature-sensitive mutants

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Summary

Seven temperature-sensitive mutants of RS virus were analyzed genetically for evidence of complementation and recombination. The results of these tests suggested that there were 3 mutually exclusive complementation groups. No evidence of recombination was obtained; however, mixed infection of cells with mutants belonging to 2 different complementation groups yielded viruses which appeared to be complementing heterozygotes.

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Author notes

  1. R. M. Chanock

    Present address: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, DHEW, National Institutes of Health, Bethesda, Maryland, USA

  2. P. F. Wright

    Present address: Children's Hospital Medical Center, 300 Longwood Avenue, 02115, Boston, MA, USA

Authors and Affiliations

  1. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, DHEW, National Institutes of Health, Bethesda, Maryland, USA

    P. F. Wright, Meera A. Gharpure & D. S. Hodes

  2. MAN Program, 5640 Fisher Lane, 20852, Roekville, MD, USA

    Meera A. Gharpure

Authors
  1. P. F. Wright
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  2. Meera A. Gharpure
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  3. D. S. Hodes
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  4. R. M. Chanock
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Wright, P.F., Gharpure, M.A., Hodes, D.S. et al. Genetic studies of respiratory syneytial virus temperature-sensitive mutants. Archiv f Virusforschung 41, 238–247 (1973). https://doi.org/10.1007/BF01252771

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  • DOI: https://doi.org/10.1007/BF01252771

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