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Failure of anticholinergic drugs to antagonize the increase in dopamine seen after gammahydroxybutyric acid and axotomy

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Summary

The increase in dopamine (DA) seen either 30 or 90 min after injection of gammahydroxybutyric acid or 90 min after axotomy of the nigrostriatal DA-fibers was not affected by i.p. injections of either atropine sulfate or atropine methyl nitrate or benztropine. These increases in DA are most probably due to feedback-mechanisms which do not involve cholinergic neurons.

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Stock, G. Failure of anticholinergic drugs to antagonize the increase in dopamine seen after gammahydroxybutyric acid and axotomy. J. Neural Transmission 44, 137–143 (1979). https://doi.org/10.1007/BF01252707

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