Melatonin concentrations in serum and urine were examined following oral administration of melatonin to dogs. Four different doses of melatonin ranging from 10 to 80 mg per kg of body weight were given. Melatonin was rapidly absorbed and reached a maximum serum level after 20–30 min, with a distribution phase of 3.5 hours and elimination half life (t1/2) of 5 hours. The fraction excreted in the urine was 0.25% of the administrated dose during the first 5 hours. These results as well as the diurnal rhythm of serum melatonin in the dog are similar to corresponding data reported in the human.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Arendt, J., Wetterberg, L., Heyden, T., Sizonenko, P. C., Paunier, L. Radioimmunoassay of melatonin: Human serum and cerebrospinal fluid. Hormone Res.8, 65–75 (1977).
Kennaway, D. J., Frith, R. G., Phillipou, G., Matthews, C. D., Seamark, R. F. A specific radioimmunoassay for melatonin in biological tissue and fluids and its validation by gas chromatography-mass spectrometry. Endocrinology101, 119–127 (1977).
Wetterberg, L., Eriksson, O., Friberg, Y., Vangbo, B. A simplified radioimmunoassay for melatonin and its application to biological fluids. Preliminary observations on the half life of plasma melatonin in man. Clin. Chem. Acta86, 169–177 (1978).
Wetterberg, L. Clinical importance of melatonin. In: Progress in Brain Research, Vol. 52 (Ariëns Kappers, J., Pévet, P., eds.), pp. 539–547. Amsterdam: Elsevier. 1979.
This study was presented September 30, 1980 by L. Wetterberg at the International Symposium on Melatonin in Bremen, Federal Republic of Germany.
About this article
Cite this article
Sääf, J., Wetterberg, L., Bäckström, M. et al. Melatonin administration to dogs. J. Neural Transmission 49, 281–285 (1980). https://doi.org/10.1007/BF01252131
- Melatonin administration
- diurnal rhythm