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Melatonin administration to dogs


Melatonin concentrations in serum and urine were examined following oral administration of melatonin to dogs. Four different doses of melatonin ranging from 10 to 80 mg per kg of body weight were given. Melatonin was rapidly absorbed and reached a maximum serum level after 20–30 min, with a distribution phase of 3.5 hours and elimination half life (t1/2) of 5 hours. The fraction excreted in the urine was 0.25% of the administrated dose during the first 5 hours. These results as well as the diurnal rhythm of serum melatonin in the dog are similar to corresponding data reported in the human.

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Additional information

This study was presented September 30, 1980 by L. Wetterberg at the International Symposium on Melatonin in Bremen, Federal Republic of Germany.

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Sääf, J., Wetterberg, L., Bäckström, M. et al. Melatonin administration to dogs. J. Neural Transmission 49, 281–285 (1980).

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Key words

  • Melatonin administration
  • diurnal rhythm
  • dog
  • pharmacokinetics