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Melatonin administration to dogs

Summary

Melatonin concentrations in serum and urine were examined following oral administration of melatonin to dogs. Four different doses of melatonin ranging from 10 to 80 mg per kg of body weight were given. Melatonin was rapidly absorbed and reached a maximum serum level after 20–30 min, with a distribution phase of 3.5 hours and elimination half life (t1/2) of 5 hours. The fraction excreted in the urine was 0.25% of the administrated dose during the first 5 hours. These results as well as the diurnal rhythm of serum melatonin in the dog are similar to corresponding data reported in the human.

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References

  1. Arendt, J., Wetterberg, L., Heyden, T., Sizonenko, P. C., Paunier, L. Radioimmunoassay of melatonin: Human serum and cerebrospinal fluid. Hormone Res.8, 65–75 (1977).

    PubMed  Google Scholar 

  2. Kennaway, D. J., Frith, R. G., Phillipou, G., Matthews, C. D., Seamark, R. F. A specific radioimmunoassay for melatonin in biological tissue and fluids and its validation by gas chromatography-mass spectrometry. Endocrinology101, 119–127 (1977).

    PubMed  Google Scholar 

  3. Wetterberg, L., Eriksson, O., Friberg, Y., Vangbo, B. A simplified radioimmunoassay for melatonin and its application to biological fluids. Preliminary observations on the half life of plasma melatonin in man. Clin. Chem. Acta86, 169–177 (1978).

    Google Scholar 

  4. Wetterberg, L. Clinical importance of melatonin. In: Progress in Brain Research, Vol. 52 (Ariëns Kappers, J., Pévet, P., eds.), pp. 539–547. Amsterdam: Elsevier. 1979.

    Google Scholar 

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This study was presented September 30, 1980 by L. Wetterberg at the International Symposium on Melatonin in Bremen, Federal Republic of Germany.

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Sääf, J., Wetterberg, L., Bäckström, M. et al. Melatonin administration to dogs. J. Neural Transmission 49, 281–285 (1980). https://doi.org/10.1007/BF01252131

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Key words

  • Melatonin administration
  • diurnal rhythm
  • dog
  • pharmacokinetics