Summary
The effect of a single i.p. injection of lithium chloride on brain monoamine synthesis and tyrosine and tryptophan levels in brain and plasma in rats was studied. Acute lithium administration was found to decrease brain tyrosine levels, which most likely was due to decreased plasma tyrosine levels. Brain tryptophan levels were mainly unaffected whereas plasma tryptophan leves were slightly decreased at 8 hours after lithium administration. Brain catecholamine synthesis was decreased at 4 hours and increased at 48 hours after the injection of lithium. Brain 5-hydroxytryptamine (5-HT) synthesis was decreased at all time intervals after the injection of lithium. It is concluded that the effects of acute lithium administration on brain monoamine synthesis are not mainly due to its effect on brain tyrosine and tryptophan levels in rats. Furthermore acute lithium administration appears to affect 5-HT synthesis to a greater extent than it affects catecholamine synthesis.
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References
Atack, C., Magnusson, T.: Individual elution of noradrenaline (together with adrenalin), dopamine, 5-hydroxytryptamine and histamine, by means of mineral acid-organic solvent mixtures. J. Pharm. Pharmacol.22, 615–627 (1970).
Berggren, U., Ahlenius, S., Engel, J.: Effects of acute lithium administration on conditioned avoidance behavior and monoamine synthesis in rats. J. Neural Transm.47, 1–10 (1980).
Carlsson, A., Davies, J. N., Kehr, W., Lindqvist, M., Atack, C.: Simultanous measurements of tyrosine and tryptophan hydroxylase activities in brainin vivo using an inhibitor of the aromatic amino acid decarboxylase. Naunyn-Schmiedeberg's Arch. Pharmacol.275, 153–168 (1972).
Carlsson, A., Kehr, W., Lindqvist, M.: The role of intraneuronal amine levels in the feed-back control of dopamine, nordrenaline and 5-hydroxytryptamine synthesis in rat brain. J. Neural Transm.39, 1–19 (1976).
Carlsson, A., Lindqvist, M.: Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino-acids in rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol.303, 157–164 (1978).
Kehr, W., Carlsson, A., Lindqvist, M.: A method for the determination of 3, 4-dihydroxyphenylalanine (DOPA) in brain. Naunyn-Schmiedeberg's Arch. Pharmacol.274, 273–280 (1972).
Lapierre, Y. D., Gagnon, A., Kokkinidis, L.: Rapid recurrance of mania following lithium withdrawal. Biol. Psychiat.15, 859–864 (1980).
Mandell, A., Knapp, S.: A neurobiological model for the symmetrical prophylactic action of lithium in bipolar affective disorder. Pharmakopsych.9, 116–126 (1976).
Perez-Cruet, J., Tagliamonte, A., Tagliamonte, P., Gessa, G. L.: Stimulation of the serotonin synthesis by lithium. J. Pharmacol. Exp. Ther.178, 325–330 (1971).
Schubert, J.: Effect of chronic lithium treatment on monoamine metabolism in rat brain. Psychopharmacol.32, 301–311 (1973).
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Berggren, U. The effect of acute lithium administration on brain monoamine synthesis and the precursor amino acids tyrosine and tryptophan in brain and plasma in rats. J. Neural Transmission 61, 175–181 (1985). https://doi.org/10.1007/BF01251911
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DOI: https://doi.org/10.1007/BF01251911