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On the mechanism of interferon induction by polynucleotides

Suppressive effect of poly(rI) · poly (rC) on the liberation of histamine by polycations

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Summary

Complexing of polynucleotides to polycationic substances enhances their uptake by mouse peritoneal cells. DEAE dextran and protamine sulfate when complexed with poly(rI) · poly(rC) lost their ability to release histamine while the complexes become very active in their interferon inducing capacity. Increased concentrations of poly(rI) · poly(rC) in the complex with protamine sulfate resulted in increase of interferon production but in decrease of histamine liberation. As the cationic character of histamine liberators is not necessary for this process, results presented here suggest, that the cell membrane may play an important role in the interferon production triggered by polynucleotides.

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  1. J. Svec

    Present address: Cancer Research Institute, Bratislava

Authors and Affiliations

  1. Cancer Research Institute, Bratislava

    P. Svec

  2. Pharmaceutical Faculty of Komensky University, Bratislava, Czechoslovakia

    J. Svec & P. Svec

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  1. J. Svec
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Svec, J., Svec, P. On the mechanism of interferon induction by polynucleotides. Archiv f Virusforschung 44, 307–312 (1974). https://doi.org/10.1007/BF01251011

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  • DOI: https://doi.org/10.1007/BF01251011

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