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A paramyxovirus-like virus isolated from pemphigus-disease in man

Electronoptical and buoyant density studies

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Summary

Electron optical studies of an infectious agent isolated from individuals suffering frompemphigus vulgaris, dermatitis herpetiformis Duhring andepidermolysis bullosa revealed a paramyxovirus-like virus. The pleomorphic but approximately spherical particles showed a mean diameter of 150 to 200 mμ, however, also extreme values of 80 and 500 mμ could be measured. Two main features, an outer envelope covered with clubshaped, 11 mμ long projections and an internal helical component consisting of elipsoidal subunits were readily observable. For the helical component an overall diameter of 18 mμ, an inner diameter of 4.5–6 mμ and a pitch height of 5–6 mμ was estimated.

After centrifugation in CsCl-density-gradients peak-infectivity-titres of Freon-purified virus were found in fractions with a medium density of 1.285 g/ml.

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Author notes

  1. G. Siegl

    Present address: Institute of Hygiene and Medical Microbiology, University of Berne, Germany

Authors and Affiliations

  1. Institute of Hygiene and Medical Microbiology, University of Berne, Germany

    E. E. A. Hahn

Authors
  1. G. Siegl
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  2. E. E. A. Hahn
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Siegl, G., Hahn, E.E.A. A paramyxovirus-like virus isolated from pemphigus-disease in man. Archiv f Virusforschung 28, 41–50 (1969). https://doi.org/10.1007/BF01250844

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  • DOI: https://doi.org/10.1007/BF01250844

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