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Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

  • T. Shiotani
  • K. Tohyama
  • K. Murase
  • S. Ishihara
  • T. Kameyama
  • T. Yamasaki
  • S. Hatanaka
  • H. Kojima
  • Y. Takasu
  • T. Nabeshima
Full Papers

Summary

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

Keywords

Nefiracetam DM-9384 cycloheximide amnesia cholineacetyltransferase 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • T. Shiotani
    • 1
  • K. Tohyama
    • 2
  • K. Murase
    • 2
  • S. Ishihara
    • 2
  • T. Kameyama
    • 2
  • T. Yamasaki
    • 1
  • S. Hatanaka
    • 1
  • H. Kojima
    • 1
  • Y. Takasu
    • 1
  • T. Nabeshima
    • 3
  1. 1.Tokyo Research and Development CenterDaiichi Pharmaceutical Co. Ltd.Tokyo
  2. 2.Department of Chemical Pharmacology, Faculty of Pharmaceutical SciencesMeijo UniversityNagoya
  3. 3.Department of Neuropsychopharmacology and Hospital PharmacyNagoya University, School of MedicineNagoyaJapan

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