Summary
The effect of γ-butyrolactone (GBL) on the accumulation of dopa after inhibition of aromatic amino acid decarboxylase was studied in rats following chronic treatment with ethanol. The GBL-induced dopa accumulation was significantly decreased in ethanol-treated rats. With the increased duration of the ethanol treatment this effect appears to be more marked in the limbic forebrain. It is suggested that chronic ethanol treatment may produce a decreased sensitivity of central GABA receptors.
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Liljequist, S., Engel, J. Attenuation of the γ-butyrolactone-induced increase in DOPA accumulation by chronic ethanol administration. J. Neural Transmission 46, 195–204 (1979). https://doi.org/10.1007/BF01250785
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DOI: https://doi.org/10.1007/BF01250785