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Changes in body temperature markedly affect striatal dopamine release and metabolism: an in vivo study


Dopamine release and metabolism in the corpus striatum increased markedly when the core body temperature of anesthetized rats was increased from 35 ° to 41 °C while temperatures below 34 ° were associated with a marked attenuation of dopamine release. These observations may have clinical relevance in cases where alterations in body temperature are associated with extrapyramidal dysfunction.

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Brannan, T., Martínez-Tica, J. & Yahr, M.D. Changes in body temperature markedly affect striatal dopamine release and metabolism: an in vivo study. J. Neural Transmission 89, 193–196 (1992).

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  • Dopamine
  • body temperature
  • Parkinson's disease
  • cerebral microdialysis