Skip to main content

Changes in body temperature markedly affect striatal dopamine release and metabolism: an in vivo study

Summary

Dopamine release and metabolism in the corpus striatum increased markedly when the core body temperature of anesthetized rats was increased from 35 ° to 41 °C while temperatures below 34 ° were associated with a marked attenuation of dopamine release. These observations may have clinical relevance in cases where alterations in body temperature are associated with extrapyramidal dysfunction.

This is a preview of subscription content, access via your institution.

References

  1. Brannan T, Bhardwaj A, Martínez-Tica J, Weinberger J, Yahr M (1990) Striatal L-dopa metabolism studied in vivo in rats with nigrostriatal lesions. J Neural Transm [P-D Sect] 2: 15–22

    Google Scholar 

  2. Busto R, Dietrich WD, Globus MY-T, Valdés I, Scheinberg P, Ginsberg MD (1987) Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 7: 729–738

    Google Scholar 

  3. Ebadi M, Pfeiffer RF, Murrin LC (1990) Pathogenesis and treatment of neuroleptic malignant syndrome. Gen Pharmacol 21: 367–386

    Google Scholar 

  4. Henderson VW, Wooten GF (1981) Neuroleptic malignant syndrome: a pathogenic role for dopamine receptor blockade? Neurology 31: 132–137

    Google Scholar 

  5. Montgomery JC, MacDonald JA (1990) Effects of temperature on nervous system: implications for behavioural performance. Am J Physiol 259: R 191-R 196

    Google Scholar 

  6. Sechi GP, Tanda F, Mutani R (1984) Fatal hyperpyrexia after withdrawal of levodopa. Neurology 34: 249–251

    Google Scholar 

  7. Slivka A, Brannan TS, Weinberger J, Knott PJ, Cohen G (1988) Increase in extracellular dopamine in the striatum during cerebral ischemia: a study utilizing cerebral microdialysis. J Neurochem 50: 1714–1718

    Google Scholar 

  8. Stahle L (1989) Effects of body temperature on brain extracellular dopamine in microdialysis experiments in the anesthetized rat. Current Separations 9: 65–66

    Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Brannan, T., Martínez-Tica, J. & Yahr, M.D. Changes in body temperature markedly affect striatal dopamine release and metabolism: an in vivo study. J. Neural Transmission 89, 193–196 (1992). https://doi.org/10.1007/BF01250671

Download citation

Keywords

  • Dopamine
  • body temperature
  • Parkinson's disease
  • cerebral microdialysis