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Effects of acute and chronic administration of phencyclidine on tyrosine hydroxylase activity in rat striatum

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Summary

Following a single dose of phencyclidine (PCP) striatal tyrosine hydroxylase (TH) activity was decreased 42% 15 min after PCP administration, but returned toward baseline levels by 45 min post-drug. Twentyfour hours after the 30th dose of PCP, TH activity remained depressed when compared to the chronic saline controls. TH activity was not further depressed 15 or 45 min after the 31st dose of PCP.

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Author notes

  1. R. C. Smith

    Present address: Texas Research Institute of Mental Sciences, Houston, Texas

Authors and Affiliations

  1. Texas Research Institute of Mental Sciences, Houston, Texas

    Dorothy Taylor, B. T. Ho & D. E. Leelavathi

  2. Department of Pharmacology, Baylor College of Medicine, Houston, Texas, USA

    R. C. Smith

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  1. R. C. Smith
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  2. Dorothy Taylor
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  3. B. T. Ho
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  4. D. E. Leelavathi
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Smith, R.C., Taylor, D., Ho, B.T. et al. Effects of acute and chronic administration of phencyclidine on tyrosine hydroxylase activity in rat striatum. J. Neural Transmission 48, 289–295 (1980). https://doi.org/10.1007/BF01250663

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  • DOI: https://doi.org/10.1007/BF01250663

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